TETRAHYDROQUINAZOLINONE DERIVATIVES AS PARP INHIBITORS

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EP 2 870 140 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	28.09.2016 Bulletin 2016/39

(45)	Mention of the grant of the patent:
	27.07.2016 Bulletin 2016/30

(21)	Application number: 13742752.2

(22)	Date of filing: 09.07.2013

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International Patent Classification (IPC):

C07D 239/90^(2006.01)
A61K 31/517^(2006.01)

C07D 239/88^(2006.01)
A61P 35/00^(2006.01)

(86)	International application number:
	PCT/IB2013/055618

(87)	International publication number:
	WO 2014/009872 (16.01.2014 Gazette 2014/03)

(54)	TETRAHYDROQUINAZOLINONE DERIVATIVES AS PARP INHIBITORS TETRAHYDROCHINAZOLINON-DERIVATE ALS PARP INHIBITOREN DERIVES DE TETRAHYDROQUINAZOLINONE COMME INHIBITEURS DE PARP

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

09.07.2012 IN KO07622012

(43)	Date of publication of application:
	13.05.2015 Bulletin 2015/20

(73)	Proprietor: Lupin Limited
	Mumbai 400055 (IN)

(72)	Inventors:
	JANA, Gourhari Pune 412 115 Maharashtra (IN) KURHADE, Sanjay, Pralhad Pune 412 115 Maharashtra (IN) JAGDALE, Arun, Rangnath Pune 412 115 Maharashtra (IN) KUKREJA, Gagan Pune 412 115 Maharashtra (IN) SINHA, Neelima Pune 412 115 Maharashtra (IN) PALLE, Venkata, P. Pune 412 115 Maharashtra (IN) KAMBOJ, Rajender, Kumar Pune 412 115 Maharashtra (IN)

(74)	Representative: McDonough, Jonathan
	Hepworth Browne 7 Wragley House Valley Road Hebden Bridge HX7 7BN Valley Road Hebden Bridge HX7 7BN (GB)

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References cited: :

EP-A1- 1 396 488

KAZUKI OHNO ET AL: "Docking study and binding free energy calculation of poly (ADP-ribose) polymerase inhibitors", JOURNAL OF MOLECULAR MODELING, SPRINGER VERLAG, DE, vol. 17, no. 2, 18 May 2010 (2010-05-18), pages 383-389, XP019877453, ISSN: 0948-5023, DOI: 10.1007/S00894-010-0728-2
ISHIDA J ET AL: "4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, vol. 15, no. 19, 1 October 2005 (2005-10-01), pages 4221-4225, XP027801419, ISSN: 0960-894X [retrieved on 2005-10-01]

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).