(19)
(11) EP 2 872 145 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
13.04.2022 Bulletin 2022/15

(45) Mention of the grant of the patent:
09.03.2022 Bulletin 2022/10

(21) Application number: 13815988.4

(22) Date of filing: 12.07.2013
(51) International Patent Classification (IPC): 
A61K 31/55(2006.01)
A61P 25/14(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 31/55; A61P 25/00; A61P 25/14; A61P 25/22; A61P 25/24; A61P 31/04; A61P 37/02; A61P 43/00
(86) International application number:
PCT/US2013/050337
(87) International publication number:
WO 2014/012034 (16.01.2014 Gazette 2014/03)

(54)

FUSED BENZAZEPINES FOR TREATMENT OF TOURETTE'S SYNDROME

KONDENSIERTE BENZAZEPINE ZUR BEHANDLUNG DES TOURETTE-SYNDROMS

BENZAZÉPINES CONDENSÉES POUR LE TRAITEMENT DU SYNDROME DE LA TOURETTE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 12.07.2012 US 201261671044 P

(43) Date of publication of application:
20.05.2015 Bulletin 2015/21

(60) Divisional application:
21170063.8 / 3919060

(73) Proprietor: Emalex Biosciences, Inc.
Chicago, IL 60611 (US)

(72) Inventors:
  • CHIPKIN, Richard, E.
    Bethesda, MD 20814 (US)
  • KWAN, Rudolf
    Summit, NJ 07901 (US)

(74) Representative: Witte, Weller & Partner Patentanwälte mbB 
Postfach 10 54 62
70047 Stuttgart
70047 Stuttgart (DE)


(56) References cited: : 
WO-A1-96/13257
WO-A1-2012/033874
WO-A1-2011/057199
   
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  • DURSUN S M ET AL: "SIMILARITIES IN THE PHARMACOLOGY OF SPONTANEOUS AND DOI-INDUCED HEAD-SHAKES SUGGEST 5HT2A RECEPTORS ARE ACTIVE UNDER PHYSIOLOGICAL CONDITIONS", PSYCHOPHARMACOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 128, no. 2, 1 January 1996 (1996-01-01), pages 198-205, XP001059606, ISSN: 0033-3158, DOI: 10.1007/S002130050125
  • QIANG L ET AL: "Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 20, no. 3, 1 February 2010 (2010-02-01), pages 836-840, XP026861816, ISSN: 0960-894X [retrieved on 2010-01-04]
  • ROGER KURLAN, M.D.: 'Tourette's Syndrome.' THE NEW ENGLAND JOURNAL OF MEDICINE vol. 363, 2010, pages 2332 - 2338, XP008176095 Retrieved from the Internet: <URL:http:JJwww.nejm.org/doi/full/ 10.1056lnejmcp 1007805>
  • DATABASE PUBMED [Online] 25 October 2006 XP055184772 Retrieved from NCBI Database accession no. 10591286 & ROMACH MK ET AL.: 'Attenuation of the euphoric effects of cocaine by the dopamine DI/D5 antagonist ecopipam (SCH 39166).' ARCH GEN PSYCHIATRY vol. 56, no. 12, 1999, pages 1101 - 1106
  • Lynn Dunlap: "TSA, Psyadon to collaborate on drug trial", , May 2011 (2011-05), Retrieved from the Internet: URL:https://missouritsa.org/2011/05/12/tsa -psyadon-to-collaborate-on-drug-trial/ [retrieved on 2017-04-11]
  • Jang-Woo Shin ET AL: "Interpretation of Animal Dose and Human Equivalent Dose for Drug Development", The Journal of Korean Oriental Medicine, 1 May 2010 (2010-05-01), pages 1-7, XP55315075, Retrieved from the Internet: URL:http://jkom.org/upload/31-3 01 [01-07].pdf [retrieved on 2016-10-31]
  • REAGAN-SHAW SHANNON ET AL: "Dose translation from animal to human studies revisited.", FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY MAR 2008, vol. 22, no. 3, March 2008 (2008-03), pages 659-661, ISSN: 1530-6860
  • Anonymous: "Clinica Trials Archive - History of Changes for Study: NCT01244633", , 8 May 2012 (2012-05-08), XP55738348, Retrieved from the Internet: URL:https://www.clinicaltrials.gov/ct2/his tory/NCT01244633?V_5=View#StudyPageTop [retrieved on 2020-10-09]
  • ARNE ASTRUP ET AL: "'Randomized Controlled Trials of the D1/D5 Antagonist Ecopipam for Weight Loss in Obese Subjects", OBESITY RESEARCH, BATON ROUGE, LA, US, vol. 15, no. 7, 7 July 2007 (2007-07-07), pages 1717-1731, XP008156118, ISSN: 1071-7323, DOI: 10.1002/HBM.22021
   
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