(19)

(11)

EP 2 872 483 A1

(12)

(43) Date of publication: 20.05.2015 Bulletin 2015/21 (21) Application number: 13817534.4 (22) Date of filing: 10.07.2013

(51) International Patent Classification (IPC):  C07C 279/26(2006.01) C07C 277/08(2006.01) A61K 31/205(2006.01) A61P 3/10(2006.01) A61P 9/10(2006.01) C07C 279/02(2006.01) A61K 31/155(2006.01) A61P 9/04(2006.01) A61P 9/06(2006.01) (86) International application number: PCT/US2013/049984 (87) International publication number: WO 2014/011814 (16.01.2014 Gazette 2014/03)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 10.07.2012 US 201261669763 P 11.07.2012 US 201261670368 P 11.07.2012 US 201261670376 P 15.03.2013 US 201313841970 (71) Applicant: Thetis Pharmaceuticals LLC Southport, Connecticut 06890 (US)	(72) Inventors: MYLARI, Banavara, L. Lutz, FL 33558 (US) SCIAVOLINO, Frank, C. Waterford, CT 06385 (US) (74) Representative: Mintz Levin Cohn Ferris Glovsky and Popeo LLP  Alder Castle 10 Noble Street London EC2V 7JX London EC2V 7JX (GB)