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(11)

EP 2 874 652 A2

(12)

(88) Date of publication A3: 27.03.2014 (43) Date of publication: 27.05.2015 Bulletin 2015/22 (21) Application number: 13822129.6 (22) Date of filing: 23.07.2013

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) (86) International application number: PCT/US2013/051747 (87) International publication number: WO 2014/018572 (30.01.2014 Gazette 2014/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 23.07.2012 US 201261674820 P (71) Applicant: Zymeworks, Inc. Vancouver, British Columbia V6H 3V9 (CA)

(72) Inventors: DIXIT, Surjit, Bhimarao Richmond, British Columbia V7E 3N5 (CA) UROSEV, Dunja Vancouver, British Columbia V5Z 4N5 (CA) D'ANGELO, Igor, Edmondo, Paolo Port Moody, British Columbia V3H 5M3 (CA) NG, Gordon, Yiu, Kon Vancouver, British Columbia V6P 2N8 (CA) (74) Representative: Wichmann, Hendrik  Wuesthoff & Wuesthoff Patentanwälte PartG mbB Schweigerstraße 2 81541 München 81541 München (DE)