ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................JBDM Ver 0.1.63 (23 May 2017) - 2999001/02876163KORRIGIERTE EUROPÄISCHE PATENTSCHRIFTB8B120180221W173deBibliographieenBibliographyfrBibliographieEP14194345.6201411212015112720160315dedede10201311291520131122DE2018022120180820150527201522201801102018022017063020180221201808C12N 15/115 20100101AFI20150331BHEP A61K 31/7088 20060101ALI20150331BHEP A61P 35/00 20060101ALI20150331BHEP deDNA-Aptamere, die E- und P-Selektine spezifisch bindenenDNA aptamers specifically binding E- and P-SelectinsfrAptamères d'ADN se liant spécifiquement E et P-sélectinesWO-A2-2004/082458WO-A2-2005/014857WO-A2-2009/140383US-A1- 2012 039 810Rassa Faryammanesh: "Selektion von DNA-Aptameren", Innovative Medizin- und Biotechnologie aus Hamburg, 9. Hamburger Studententagung, 2. Mai 2012 (2012-05-02), XP55173222, Gefunden im Internet: URL:http://www.baytobio.de/newsticker/2012 /05/Tagungsband_Studententagung.pdf [gefunden am 2015-03-03]CINDY MEYER ET AL: "Cell-Specific Aptamers as Emerging Therapeutics", JOURNAL OF NUCLEIC ACIDS, Bd. 108, Nr. 10, 28. August 2011 (2011-08-28), Seiten 3900-18, XP55173341, DOI: 10.1021/ja043285eKRISTINA W. THIEL ET AL: "Therapeutic Applications of DNA and RNA Aptamers", OLIGONUCLEOTIDES, Bd. 19, Nr. 3, 5. August 2009 (2009-08-05) , Seiten 209-222, XP055078801, ISSN: 1545-4576, DOI: 10.1089/oli.2009.0199AMAN P. MANN ET AL: "Identification of Thioaptamer Ligand against E-Selectin: Potential Application for Inflamed Vasculature Targeting", PLOS ONE, Bd. 5, Nr. 9, 30. September 2010 (2010-09-30), Seite e13050, XP55173310, DOI: 10.1371/journal.pone.0013050ROBERT D. JENISON ET AL: "Oligonucleotide Inhibitors of P-Selectin-Dependent Neutrophil-Platelet Adhesion", ANTISENSE AND NUCLEIC ACID DRUG DEVELOPMENT, Bd. 8, Nr. 4, August 1998 (1998-08), Seiten 265-279, XP55173327, ISSN: 1087-2906, DOI: 10.1089/oli.1.1998.8.265W. ZHAO ET AL: "Mimicking the inflammatory cell adhesion cascade by nucleic acid aptamer programmed cell-cell interactions", THE FASEB JOURNAL, Bd. 25, Nr. 9, 7. Juni 2011 (2011-06-07), Seiten 3045-3056, XP55173324, ISSN: 0892-6638, DOI: 10.1096/fj.10-178384D. R. GUTSAEVA ET AL: "Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease", BLOOD, Bd. 117, Nr. 2, 6. Oktober 2010 (2010-10-06), Seiten 727-735, XP55173307, ISSN: 0006-4971, DOI: 10.1182/blood-2010-05-285718RINGQUIST S ET AL: "ANTI-L-SELECTIN OLIGONUCLEOTIDE LIGANDS RECOGNIZE CD62L-POSITIVE LEUKOCYTES: BINDING AFFINITY AND SPECIFICITY OF UNIVALENT AND BIVALENT LIGANDS", CYTOMETRY, ALAN LISS, NEW YORK, US, Bd. 33, 12. Dezember 1998 (1998-12-12), Seiten 394-405, XP002927384, ISSN: 0196-4763, DOI: 10.1002/(SICI)1097-0320(19981201)33:4<394: :AID-CYTO2>3.0.CO;2-0RASSA FARYAMMANESH ET AL: "SDA, a DNA Aptamer Inhibiting E- and P-Selectin Mediated Adhesion of Cancer and Leukemia Cells, the First and Pivotal Step in Transendothelial Migration during Metastasis Formation", PLOS ONE, Bd. 9, Nr. 4, 3. April 2014 (2014-04-03), Seite e93173, XP55173336, DOI: 10.1371/journal.pone.0093173Rassa Faryammanesh: "Selektion und Charakterisierung Selektin-spezifischer DNA- Aptamere", Ph. D. thesis, 2014, XP55173330, Hamburg, DE Gefunden im Internet: URL:http://ediss.sub.uni-hamburg.de/vollte xte/2014/6805/pdf/Dissertation.pdf [gefunden am 2015-03-03]Faryammanesh, RassaSuhrenkamp 24a22335 HamburgDEHahn, UlrichHorstweg 1022391 HamburgDESchumacher, UdoStormsweg 1222085 HamburgDEWicklein, DanielSaselheider Weg 52a22159 HamburgDEUniversitätsklinikum Hamburg-Eppendorf101047586PAT 1464 EPMartinistrasse 5220246 HamburgDEStüven, Ralfet al100756778Pohl & Partner Patentanwälte Kirchenhang 32 b21073 HamburgDEALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTR