(19)

(11)

EP 2 879 692 A1

(12)

(43) Date of publication: 10.06.2015 Bulletin 2015/24 (21) Application number: 13753823.7 (22) Date of filing: 05.08.2013

(51) International Patent Classification (IPC):  A61K 38/17(2006.01) C07K 16/28(2006.01) A61P 9/10(2006.01) A61K 48/00(2006.01) C12N 15/113(2010.01) (86) International application number: PCT/EP2013/066426 (87) International publication number: WO 2014/020184 (06.02.2014 Gazette 2014/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 03.08.2012 EP 12179295 17.04.2013 EP 13164109 (71) Applicant: Max-Delbrück-Centrum für Molekulare Medizin (MDC) 13125 Berlin (DE)	(72) Inventors: GOTTHARDT, Michael 10439 Berlin (DE) FREIBERG, Fabian 10407 Berlin (DE) (74) Representative: Hoppe, Georg Johannes  Darani Anwaltskanzlei Beuckestrasse 20 14163 Berlin 14163 Berlin (DE)