(19)

(11)

EP 2 880 169 A1

(12)

(43) Date of publication: 10.06.2015 Bulletin 2015/24 (21) Application number: 13744530.0 (22) Date of filing: 31.07.2013

(51) International Patent Classification (IPC):  C12N 15/79(2006.01) (86) International application number: PCT/EP2013/066096 (87) International publication number: WO 2014/020069 (06.02.2014 Gazette 2014/06)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 02.08.2012 EP 12179021 (71) Applicant: F.Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: AUER, Johannes 82445 Schwaigen (DE) BADER, Martin 82377 Penzberg (DE) DENGL, Stefan 80333 Muenchen (DE) LORENZ, Stefan 82377 Penzberg (DE) SEEBER, Stefan 82404 Sindelsdorf (DE) (74) Representative: Burger, Alexander et al Roche Diagnostics GmbH Patent Department (LPP.....6164) P.O.Box 11 52 82372 Penzberg 82372 Penzberg (DE)