(19)
(11) EP 2 882 435 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
03.01.2024 Bulletin 2024/01

(45) Mention of the grant of the patent:
17.03.2021 Bulletin 2021/11

(21) Application number: 13829445.9

(22) Date of filing: 09.08.2013
(51) International Patent Classification (IPC): 
A61K 31/395(2006.01)
A61K 9/00(2006.01)
A61P 31/06(2006.01)
A61K 31/496(2006.01)
C07D 498/08(2006.01)
 A61K 31/495(2006.01)
C07D 491/00(2006.01)
A61P 31/04(2006.01)
A61K 9/48(2006.01)
(52) Cooperative Patent Classification (CPC):
A61K 31/496; A61K 9/4866; C07D 498/08; A61P 31/04; A61P 31/06
(86) International application number:
PCT/BG2013/000041
(87) International publication number:
WO 2014/026254 (20.02.2014 Gazette 2014/08)

(54)

Pharmaceutical formulations containing 3-(4-cinnamyl-L-piperazinyl) amino derivatives of 3-formylrifamycin S

Pharmazeutische Formulierungen mit 3-(4-Cinnamyl-L-piperazinyl)aminoderivaten von 3-Formylrifamycin S

Formulations pharmaceutiques contenant des derives 3-(4-cinnamyl-l-piperazinyl)amino de 3-formylrifamycine S

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 13.08.2012 BG 11128812

(43) Date of publication of application:
17.06.2015 Bulletin 2015/25

(73) Proprietors:
  • Adipharm Ead
    1700 Sofia (BG)
  • Fudulov, Bozhidar Lyubenov
    1504 Sofia (BG)
  • Fudulov, Lyibomir Bozhidarov
    1504 Sofia (BG)
  • Ninov, Kiril Asenov
    1505 Sofia (BG)
  • Apostolova-Dimova, Velichka Llieva
    1784 Sofia (BG)
  • Stefanova, Evtimia Ivanova
    1408 Sofia (BG)
  • Koytchev, Rossen Krumov
    15366 Neuenhagen, Berlin (DE)
  • Ditchev Consulting ood
    1404 Sofia (BG)

(72) Inventors:
  • KONSTANTINOVA, Rumyana Gueorguieva
    deceased (BG)
  • NINOV, Kiril Asenov
    1505 Sofia (BG)
  • APOSTOLOVA-DIMOVA, Velichka llieva
    1784 Sofia (BG)
  • STEFANOVA, Evtimia Ivanova
    1408 Sofia (BG)
  • KOYTCHEV, Rossen Krumov
    15366 Neuenhagen Berlin (DE)

(74) Representative: Nesheva, Valentina Velikova 
Patent Universe 45, Solunska Street, et. 3, ap. 14
1000 Sofia
1000 Sofia (BG)


(56) References cited: : 
US-A- 4 193 920
US-A- 5 095 108
US-B1- 6 476 036
 US-A- 4 918 066
US-A- 5 095 108
US-B1- 6 476 036
   
  • DIMOVA VELICHKA ET AL: "Experimental and Clinical Studies on Rifacinna - The New Effective Antituberculous Drug (Review)", RECENT PATENTS ON ANTI-INFECTIVE DRUG DISCOVERY, vol. 5, no. 1, 1 January 2010 (2010-01-01) , pages 76-90, XP055245321, NL ISSN: 1574-891X, DOI: 10.2174/157489110790112572
  • FERNANDO MARTNEZ R ET AL: "Hydrazones from hydroxy naphthaldehydes and-aminoheterocycles: structure and stereodynamics", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 67, no. 11, 22 January 2011 (2011-01-22), pages 2025-2034, XP028148967, ISSN: 0040-4020, DOI: 10.1016/J.TET.2011.01.065 [retrieved on 2011-01-28]
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).