(19)
(11) EP 2 883 052 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
13.03.2019 Bulletin 2019/11

(45) Mention of the grant of the patent:
26.09.2018 Bulletin 2018/39

(21) Application number: 13753421.0

(22) Date of filing: 12.08.2013
(51) International Patent Classification (IPC): 
G01N 33/564(2006.01)
C07K 14/47(2006.01)
(86) International application number:
PCT/EP2013/066845
(87) International publication number:
WO 2014/023852 (13.02.2014 Gazette 2014/07)

(54)

BIOMARKERS

BIOMARKER

BIOMARQUEURS


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 10.08.2012 US 201261681638 P

(43) Date of publication of application:
17.06.2015 Bulletin 2015/25

(73) Proprietor: Istituto Superiore di Sanità
00161 Roma (IT)

(72) Inventors:
  • LAVIOLA, Giovanni
    I-00161 Roma (IT)
  • ADRIANI, Walter
    I-00161 Roma (IT)
  • PORFIRIO, Maria Cristina
    Roma (IT)
  • CURATOLO, Paolo
    Roma (IT)
  • GRANSTREM, Oleg
    St. Petersburg 194100 (RU)

(74) Representative: Predazzi, Valentina 
Società Italiana Brevetti S.p.A. Piazza di Pietra, 39
00186 Roma
00186 Roma (IT)


(56) References cited: : 
   
  • W Adriani ET AL: "Blood titers of auto-antibodies to DAT as biomarkers for the risk of alcoholism: The case of positive familiarity (P13)" In: "Needs and Challenges in Translational Medicine: filling the gap between basic research and clinical applications; Abstract book of the international meeting at the Istituto Superiore di Sanita, Rome, Italy, October 1-3, 2008", 1 October 2008 (2008-10-01), XP055084418, page 90, the whole document, in particular l. 14-16 of abstract
  • A. M. ANDRES ET AL: "Heterogeneous Rate of Protein Evolution in Serotonin Genes", MOLECULAR BIOLOGY AND EVOLUTION, vol. 24, no. 12, 29 June 2007 (2007-06-29) , pages 2707-2715, XP055084424, ISSN: 0737-4038, DOI: 10.1093/molbev/msm202 -& DATABASE UniProt [Online] 1 October 2000 (2000-10-01), "RecName: Full=Transporter; Flags: Fragment;", XP002715108, retrieved from EBI accession no. UNIPROT:Q9NYN7 Database accession no. Q9NYN7
  • UJJWAL K ROUT ET AL: "Presence of GAD65 autoantibodies in the serum of children with autism or ADHD", EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, STEINKOPFF-VERLAG, DA, vol. 21, no. 3, 10 February 2012 (2012-02-10), pages 141-147, XP035026171, ISSN: 1435-165X, DOI: 10.1007/S00787-012-0245-1
  • Giovanni Laviola ET AL: "Implication of autoantibodies to receptor fragments in etiology of compulsive behavior and drug addiction" In: "Istituto Superiore di Sanita: ISS-NIH Collaborative Programme: final report of the projects", 1 May 2009 (2009-05-01), XP055084435, pages 374-377, the whole document, in particular section "state of the art" spanning p. 374 and 375
  • MACRI S ET AL: "Resilience and vulnerability are dose-dependently related to neonatal stressors in mice", HORMONES AND BEHAVIOR, ACADEMIC PRESS, NEW YORK, NY, US, vol. 56, no. 4, 1 October 2009 (2009-10-01), pages 391-398, XP026683035, ISSN: 0018-506X, DOI: 10.1016/J.YHBEH.2009.07.006 [retrieved on 2009-07-24]
  • VANDENBERGH D J ET AL: "A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs", MOLECULAR BRAIN RESEARCH, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 15, no. 1-2, 1 September 1992 (1992-09-01), pages 161-166, XP024331783, ISSN: 0169-328X, DOI: 10.1016/0169-328X(92)90165-8 [retrieved on 1992-09-01] -& DATABASE UniProt [Online] 1 April 1993 (1993-04-01), "RecName: Full=Sodium-dependent dopamine transporter; Short=DA transporter; Short=DAT; AltName: Full=Solute carrier family 6 member 3;", XP002715109, retrieved from EBI accession no. UNIPROT:Q01959 Database accession no. Q01959
   
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