(19)
(11) EP 2 890 703 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
06.03.2019 Bulletin 2019/10

(45) Mention of the grant of the patent:
12.09.2018 Bulletin 2018/37

(21) Application number: 13739727.9

(22) Date of filing: 23.07.2013
(51) International Patent Classification (IPC): 
C07H 15/207(2006.01)
C08B 37/00(2006.01)
A61P 33/02(2006.01)
A61K 39/00(2006.01)
G01N 33/569(2006.01)
 C07H 1/02(2006.01)
A61K 39/002(2006.01)
A61K 39/012(2006.01)
A61K 47/64(2017.01)
(86) International application number:
PCT/EP2013/065559
(87) International publication number:
WO 2014/016317 (30.01.2014 Gazette 2014/05)

(54)

SYNTHESIS OF DIVERSE GLYCOSYLPHOSPHATIDYLINOSITOL GLYCANS FROM TOXOPLASMA GONDII AND THEIR APPLICATION AS VACCINES AND DIAGNOSTICS

SYNTHESE UNTERSCHIEDLICHER GLYCOSYLPHOSPHATIDYLINOSITOL-GLYCANE AUS TOXOPLASMA GONDII UND DEREN ANWENDUNG ALS IMPFSTOFFE UND DIAGNOSEMITTEL

SYNTHÈSE DE DIVERS GLYCOSYLPHOSPHATIDYLINOSITOL GLYCANES À PARTIR DE TOXOPLASMA GONDII ET LEUR APPLICATION EN TANT QUE VACCINS ET OUTILS DE DIAGNOSTIC

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 24.07.2012 EP 12177588

(43) Date of publication of application:
08.07.2015 Bulletin 2015/28

(73) Proprietor: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
80539 München (DE)

(72) Inventors:
  • AZZOUZ, Nahid
    10711 Berlin (DE)
  • GÖTZE, Sebastian
    12163 Berlin (DE)
  • SEEBERGER, Peter H.
    14532 Klein Machnow (DE)
  • SILVA, Daniel Varon
    14165 Berlin (DE)
  • TSAI, Yu-Hsuan
    12207 Berlin (DE)

(74) Representative: Arth, Hans-Lothar 
ABK Patent Attorneys Jasminweg 9
14052 Berlin
14052 Berlin (DE)


(56) References cited: : 
WO-A1-97/10249
   
  • YU-HSUAN TSAI ET AL: "A General Method for Synthesis of GPI Anchors Illustrated by the Total Synthesis of the Low-Molecular-Weight Antigen from Toxoplasma gondii", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 50, no. 42, 10 October 2011 (2011-10-10), pages 9961-9964, XP055039696, ISSN: 1433-7851, DOI: 10.1002/anie.201103483
  • YONG-UK KWON ET AL: "Total syntheses of fully lipidated glycosylphosphatidylinositol anchors of Toxoplasma gondii", CHEMICAL COMMUNICATIONS, no. 17, 1 January 2005 (2005-01-01), page 2280, XP055039709, ISSN: 1359-7345, DOI: 10.1039/b501373a
  • Françoise Debierre-Grockiego ET AL: "Activation of TLR2 and TLR4 by Glycosylphosphatidylinositols Derived from Toxoplasma gondii", J Immunol 2007; 179, 15 July 2007 (2007-07-15), pages 1129-1137, XP055039705, Retrieved from the Internet: URL:http://www.jimmunol.org/content/179/2/ 1129.full.pdf [retrieved on 2012-10-01]
  • KLAUS PEKARI ET AL: "Synthesis of the Fully Phosphorylated GPI Anchor Pseudohexasaccharide of Toxoplasma g ondii", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 22, 1 November 2001 (2001-11-01), pages 7432-7442, XP055039716, ISSN: 0022-3263, DOI: 10.1021/jo015840q
  • KLAUS PEKARI ET AL: "A Variable Concept for the Preparation of Branched Glycosyl Phosphatidyl Inositol Anchors", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 4, 1 February 2003 (2003-02-01), pages 1295-1308, XP055039715, ISSN: 0022-3263, DOI: 10.1021/jo026380j
  • KWON YONG-UK ET AL: "Assembly of a series of malarial glycosylphosphatidylinositol anchor oligosaccharides", CHEMISTRY - A EUROPEAN JOURNAL, WILEY - V C H VERLAG GMBH & CO. KGAA, WEINHEIM, DE, vol. 11, no. 8, 8 April 2005 (2005-04-08), pages 2493-2504, XP002463517, ISSN: 0947-6539, DOI: 10.1002/CHEM.200400934
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).