(19)

(11)

EP 2 892 414 A1

(12)

(43) Date of publication: 15.07.2015 Bulletin 2015/29 (21) Application number: 13835171.3 (22) Date of filing: 10.09.2013

(51) International Patent Classification (IPC):  A61B 3/10(2006.01) G01B 9/02(2006.01) (86) International application number: PCT/US2013/059047 (87) International publication number: WO 2014/040070 (13.03.2014 Gazette 2014/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 10.09.2012 US 201261699257 P 15.03.2013 US 201361799502 P (71) Applicant: Oregon Health & Science University Portland, OR 97239 (US)	(72) Inventors: HUANG, David Portland, OR 97239-3104 (US) JIA, Yali Portland, OR 97229 (US) TOKAYER, Jason Visalia, CA 93292 (US) TAN, Ou Portland, OR 97229 (US) (74) Representative: Bosia, Alessandra et al STUDIO TORTA S.p.A. Via Viotti, 9 10121 Torino 10121 Torino (IT)