(19)

(11)

EP 2 892 618 A1

(12)

(43) Date of publication: 15.07.2015 Bulletin 2015/29 (21) Application number: 13835772.8 (22) Date of filing: 21.06.2013

(51) International Patent Classification (IPC):  A61P 25/28(2006.01) C07H 21/02(2006.01) A61K 31/7088(2006.01) (86) International application number: PCT/US2013/046990 (87) International publication number: WO 2014/039138 (13.03.2014 Gazette 2014/11)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 06.09.2012 US 201213605206 (71) Applicant: Trustees of Dartmouth College Hanover, NH 03755-1404 (US)	(72) Inventors: CHANG, Ta-Yuan Etna, NH 03750 (US) CHANG, Catherine, C.Y. Etna, NH 03750 (US) BRYLEVA, Elena Lebanon, NH 03766 (US) MURPHY, Stephanie West Lebanon, NH 03784 (US) ROGERS, Maximillian, A. White River Junction, VT 05001 (US) (74) Representative: O'Connell, Maura  FRKelly 27 Clyde Road Ballsbridge Dublin 4 Dublin 4 (IE)