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(11)

EP 2 897 561 A1

(12)

(43) Date of publication: 29.07.2015 Bulletin 2015/31 (21) Application number: 12884789.4 (22) Date of filing: 21.09.2012

(51) International Patent Classification (IPC):  A61F 13/02(2006.01) A61L 15/42(2006.01) D01D 5/00(2006.01) A61L 15/22(2006.01) D04H 3/16(2006.01) (86) International application number: PCT/US2012/056548 (87) International publication number: WO 2014/046669 (27.03.2014 Gazette 2014/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (71) Applicant: Washington University Saint Louis, MO 63130 (US)	(72) Inventor: MACEWAN, Matthew R. St. Louis, Mississippi 63110 (US) (74) Representative: Smaggasgale, Gillian Helen  WP Thompson 55 Drury Lane London WC2B 5SQ London WC2B 5SQ (GB)