(19)
(11) EP 2 913 393 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
26.02.2020 Bulletin 2020/09

(45) Mention of the grant of the patent:
08.01.2020 Bulletin 2020/02

(21) Application number: 15156823.5

(22) Date of filing: 17.11.2005
(51) International Patent Classification (IPC): 
C12N 5/0797(2010.01)
A01N 63/00(2020.01)
A61P 25/00(2006.01)
A61K 35/30(2015.01)
A61K 9/00(2006.01)

(54)

Transplantation of human neural cells for treatment of neurodegenerative conditions

Transplantation menschlicher Nervenzellen zur Behandlung neurodegenerativer Erkrankungen

Transplantation de cellules neurales humaines pour le traitement d'affections neurodégénératives


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 17.11.2004 US 629220

(43) Date of publication of application:
02.09.2015 Bulletin 2015/36

(62) Application number of the earlier application in accordance with Art. 76 EPC:
05851748.3 / 1814979

(73) Proprietor: Seneca Biopharma, Inc.
Germantown, MD 20876 (US)

(72) Inventors:
  • Marsala, Martin
    Solana Beach, CA 92075 (US)
  • Johe, Karl K.
    Sunny Isles, Florida 33160 (US)
  • Hazel, Thomas G.
    North Potomac, MD 20878 (US)
  • Kakinohama, Osamu
    San Diego, CA 92122 (US)
  • Koliatsos, Vassilis
    Ruxton, MD 21104 (US)
  • Yan, Jun
    Annandale, VA 22003 (US)
  • Reier, Paul J.
    Gainesville, FL 32607 (US)
  • Velardo, Margaret J.
    Falls Church, VA 22044-2723 (US)

(74) Representative: MacLean, Martin Robert et al
Mathys & Squire LLP
The Shard 32 London Bridge Street London SE1 9SG
The Shard 32 London Bridge Street London SE1 9SG (GB)


(56) References cited: : 
WO-A2-03/046141
   
  • LLADO J ET AL: "Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors", MOLECULAR AND CELLULAR NEUROSCIENCES, SAN DIEGO, US, vol. 27, no. 3, 1 November 2004 (2004-11-01), pages 322-331, XP004613831, ISSN: 1044-7431
  • OKA S ET AL: "Autologous transplantation of expanded neural precursor cells into the demyelinated monkey spinal cord", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1030, no. 1, 5 November 2004 (2004-11-05), pages 94-102, XP004657006, ISSN: 0006-8993
  • MARSALA MARTIN ET AL: "Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia", EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 20, no. 9, 12 October 2004 (2004-10-12), pages 2401-2414, XP002488033, ISSN: 0953-816X
  • JAIN MEENA ET AL: "GABAergic immunoreactivity is predominant in neurons derived from expanded human neural precursor cells in vitro.", EXPERIMENTAL NEUROLOGY, vol. 182, no. 1, July 2003 (2003-07), pages 113-123, XP002488034, ISSN: 0014-4886
  • CUMMINGS BRIAN J ET AL: "Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 39, September 2005 (2005-09) , pages 14069-14074, XP002488035, ISSN: 0027-8424
  • LEPORE A C ET AL: "Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1045, no. 1-2, 31 May 2005 (2005-05-31), pages 206-216, XP004904364, ISSN: 0006-8993
  • FUJIWARA YASUSHI ET AL: "Intravenously injected neural progenitor cells of transgenic rats can migrate to the injured spinal cord and differentiate into neurons, astrocytes and oligodendrocytes", NEUROSCIENCE LETTERS, vol. 366, no. 3, 19 August 2004 (2004-08-19), pages 287-291, XP002488036, ISSN: 0304-3940
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).