| (19) |
 |
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(11) |
EP 2 913 675 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
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28.10.2015 Bulletin 2015/44 |
| (43) |
Date of publication A2: |
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02.09.2015 Bulletin 2015/36 |
| (22) |
Date of filing: 26.02.2015 |
|
| (51) |
International Patent Classification (IPC):
|
|
| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
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Designated Extension States: |
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BA ME |
| (30) |
Priority: |
28.02.2014 EP 14157199
|
| (71) |
Applicant: GA Generic Assays GmbH |
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15827 Dahlewitz (DE) |
|
| (72) |
Inventor: |
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- Roggenbuck, Dirk
15344 Strausberg (DE)
|
| (74) |
Representative: Buchanan, Luke Noel |
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Hertin und Partner
Rechts- und Patentanwälte PartG mbB
Kurfürstendamm 54/55
10707 Berlin
10707 Berlin (DE) |
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| |
|
| (54) |
GP2 isoforms and their use in autoantibody capture |
(57) The invention relates to a method for binding or capturing autoantibodies directed
to various Glycoprotein 2 (GP2) isoforms. In particular the invention provides an
in vitro method for the diagnosis of an autoimmune disorder by the detection of autoantibodies
that bind one or more isoforms of GP2. The invention is characterised by the provision
of multiple isoforms of GP2 as autoantibody targets and encompasses the practical
utilisation of the finding that the isoform specificity of anti-GP2 autoantibodies
enables determination of particular autoimmune diseases. The invention also provides
a kit developed for carrying out the claimed method. The present invention is useful
for determining whether a sample from an individual comprises autoantibodies associated
with an autoimmune disease, and for differentiating between multiple autoimmune diseases
that exhibit similar symptoms, such as Celiac disease (CeD), Crohn's disease (CD)
and/or ulcerative colitis (UC).