(19)

(11)

EP 2 916 884 A1

(12)

(43) Date of publication: 16.09.2015 Bulletin 2015/38 (21) Application number: 13786747.9 (22) Date of filing: 05.11.2013

(51) International Patent Classification (IPC):  A61M 1/12(2006.01) A61M 1/10(2006.01) (86) International application number: PCT/GB2013/052889 (87) International publication number: WO 2014/072695 (15.05.2014 Gazette 2014/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 06.11.2012 GB 201219958 (71) Applicants: Queen Mary University of London London Greater London E1 4NS (GB) Barts Health NHS Trust, The Royal London Hospital London, Greater London E1 1BB (GB)	(72) Inventors: KORAKIANITIS, Theodosios Shropshire SY1 2AF (GB) ROTHMAN, Martin Terry Santa Rosa California 95409 (US) (74) Representative: Forsythe, Dominic  J A Kemp 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)