(19)

(11)

EP 2 922 869 A2

(12)

(88) Date of publication A3: 24.07.2014 (43) Date of publication: 30.09.2015 Bulletin 2015/40 (21) Application number: 13802811.3 (22) Date of filing: 25.11.2013

(51) International Patent Classification (IPC):  C07K 14/705(2006.01) A61K 38/17(2006.01) C07K 7/04(2006.01) A61K 38/03(2006.01) (86) International application number: PCT/US2013/071719 (87) International publication number: WO 2014/082042 (30.05.2014 Gazette 2014/22)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 25.11.2012 US 201261729626 P 12.03.2013 US 201361778084 P (71) Applicant: The Regents of the University of California Oakland, CA 94607 (US)	(72) Inventors: TURLEY, Eva, A. London, Ontario N6B 2A3 (CA) BAHRAMI, Seyed, Bahram Menlo Park, CA 94025-6911 (US) BISSELL, Mina, J. Berkeley, California 94708 (US) (74) Representative: Potter Clarkson LLP  The Belgrave Centre Talbot Street Nottingham NG1 5GG Nottingham NG1 5GG (GB)