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EP 2 925 129 A1

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(43) Date of publication: 07.10.2015 Bulletin 2015/41 (21) Application number: 12883358.9 (22) Date of filing: 24.08.2012

(51) International Patent Classification (IPC):  A01N 43/38(2006.01) C07D 209/82(2006.01) A61K 31/405(2006.01) (86) International application number: PCT/US2012/052283 (87) International publication number: WO 2014/031125 (27.02.2014 Gazette 2014/09)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (71) Applicant: Board of Regents of the University of Texas System Austin, TX 78701 (US)	(72) Inventors: MCKNIGHT, Steven L. Dallas, Texas 75209 (US) PIEPER, Andrew A. Plano, Texas 75093 (US) READY, Joseph M. Carrollton, Texas 75007 (US) DE BRABANDER, Jef, K. Flower Mound, Texas 75022 (US) (74) Representative: Wills, Andrew Jonathan et al Mewburn Ellis LLP City Tower 40 Basinghall Street London EC2V 5DE London EC2V 5DE (GB)