ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................*JBDM Ver 0.1.67 (18 Oct 2017) - 2999001/0The file contains technical information submitted after the application was filed and not included in this specification2925340CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120190724W173deBibliographieenBibliographyfrBibliographieEP13857618.6201311202015061920180213enenen201261729018 P20121121US2019072420193020151007201541201905082019192018112720190724201930A61K 38/34 20060101AFI20181112BHEP A61K 38/06 20060101ALI20181112BHEP A61K 38/07 20060101ALI20181112BHEP A61K 8/64 20060101ALI20181112BHEP A61Q 17/04 20060101ALI20181112BHEP A61Q 19/00 20060101ALI20181112BHEP C07K 5/097 20060101ALI20181112BHEP C07K 5/117 20060101ALI20181112BHEP A61Q 19/04 20060101ALI20181112BHEP A61Q 19/08 20060101ALI20181112BHEP A61K 38/00 20060101ALI20181112BHEP A61P 17/00 20060101ALI20181112BHEP A61P 35/00 20060101ALI20181112BHEP dePHARMAZEUTISCHE ZUSAMMENSETZUNGEN ENTHALTEND SELEKTIVE AGONISTEN DES MELANOCORTIN-1-REZEPTORS ZUR VERWENDUNG IN THERAPIEVERFAHRENenPHARMACEUTICAL COMPOSITIONS COMPRISING SELECTIVE AGONISTS OF MELANOCORTIN 1 RECEPTOR AND THEIR USE IN THERAPEUTIC METHODSfrCOMPOSITIONS PHARMACEUTIQUES COMPRENANT DES AGONISTES SÉLECTIFS DU RÉCEPTEUR DE LA MÉLANOCORTINE 1, ET LEUR UTILISATION DANS UNE MÉTHODE THÉRAPEUTIQUEWO-A1-2011/063366US-A1- 2006 003 386US-A1- 2010 216 655HOLDER JERRY RYAN ET AL: "STRUCTURE-ACTIVITY RELATIONSHIPS OF THE MELANOCORTIN TETRAPEPTIDE AC-HIS-DPHE-ARG-TRP-NH2 AT THE MOUSE MELANOCORTIN RECEPTORS: PART 2 MODIFICATIONS AT THE PHE POSITION", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 45, no. 14, 1 July 2002 (2002-07-01), pages 3073-3081, XP009077300, ISSN: 0022-2623, DOI: 10.1021/JM010524PYANG Y ET AL: "Novel binding motif of ACTH analogues at the melanocortin receptors", BIOCHEMISTRY 20091020 AMERICAN CHEMICAL SOCIETY USA, vol. 48, no. 41, 20 October 2009 (2009-10-20), pages 9775-9784, XP055270052, DOI: 10.1021/BI900634ECHEN M ET AL: "Functional characterization of the modified melanocortin peptides responsible for ligand selectivity at the human melanocortin receptors", PEPTIDES, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 11, 1 November 2006 (2006-11-01), pages 2836-2845, XP027957587, ISSN: 0196-9781 [retrieved on 2006-11-01]KOIKOV L N ET AL: "Sub-Nanomolar hMC1R Agonists by End-Capping of the Melanocortin Tetrapeptide His-D-Phe-Arg-Trp-NH2", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 13, 1 January 2003 (2003-01-01), pages 2647-2650, XP002342336, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(03)00552-3ABDEL-MALEK ZALFA A ET AL: "alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes", PIGMENT CELL & MELANOMA RESEARCH, vol. 22, no. 5, October 2009 (2009-10), pages 635-644, XP009189878,RUWE A R ET AL: "Semi-rigid tripeptide agonists of melanocortin receptors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 19, no. 17, 1 September 2009 (2009-09-01), pages 5176-5181, XP026458585, ISSN: 0960-894X [retrieved on 2009-07-09]KOIKOV ET AL.: 'Analogs of sub-nanomolar hMC1 R agonist LK-184 [Ph( CH 2) 3CO-His-D-Phe-Arg-Trp-NH2). An additional binding site within the human melanocortin receptor 1?' BIOORGANIC & MEDICINAL CHEMISTRY LETTERS., [Online] vol. 14, 09 June 2004, pages 3997 - 4000, XP055213969 Retrieved from the Internet: <URL:http://www.sciencedirect.com/ science /article/pii/S0960894X04006900>CATANIA, A.: 'Melanocortins: Multiple Actions and Therapeutic Potential' ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY vol. 681, 2010, XP055263088 ISBN: 978-1-4419-6353-6 Retrieved from the Internet: <URL:http://f3.tiera.ru/llgenesis/575-579/5 76000/103eeea76e1380c962de22f451fb36c24.>SINGH ET AL.: 'Incorporation of a Bioactive Reverse-Turn Heterocycle into a Peptide Template Using Solid-Phase Synthesis To Probe Melanocortin Receptor Selectivity and Ligand Conformations by 2D 1 H NMR' J. MED. CHEM., [Online] vol. 54, 09 February 2011, pages 1379 - 1390, XP055213971 Retrieved from the Internet: <URL:http://pubs.acs.org/doi/abs/10.1021/jm 101425m.>20161207ABDEL-MALEK, Zalfa, A.3307 Glenhurst PlaceCincinnati, OH 45209USKOIKOV, Leonid4577 AnthonyStreetCincinnati, OH 45233USKNITTEL, James, J.159 Barton AvenueBelchertown, MA 01007USUniversity Of Cincinnati101142724P37169EP/MRM51 Goodman Drive Suite 240Cincinnati, OH 45221-0829USMoore, Michael Richardet al101084582Keltie LLP No.1 London BridgeLondon SE1 9BAGBALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTRUS201307103320131120enWO201408184620140530201422