(19)

(11)

EP 2 925 729 A1

(12)

(43) Date of publication: 07.10.2015 Bulletin 2015/41 (21) Application number: 13789821.9 (22) Date of filing: 15.11.2013

(51) International Patent Classification (IPC):  C07D 239/95(2006.01) A61P 31/12(2006.01) A61K 31/505(2006.01) (86) International application number: PCT/EP2013/073901 (87) International publication number: WO 2014/076221 (22.05.2014 Gazette 2014/21)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 16.11.2012 EP 12192970 (71) Applicant: Janssen Sciences Ireland UC Little Island, County Cork (IE)

(72) Inventors: LAST, Stefaan, Julien B-2547 Lint (BE) MC GOWAN, David, Craig B-1150 Brussel (BE) EMBRECHTS, Werner B-2340 Beerse (BE) PIETERS, Serge, Maria, Aloysius NL-4562 AR Hulst (NL) JONCKERS, Tim, Hugo, Maria B-2220 Heist-op-den-Berg (BE) RABOISSON, Pierre, Jean-Marie, Bernard B-1331 Rosières (BE) (74) Representative: Daelemans, Frank F.R.  Janssen Pharmaceutica N.V. J&J Patent Law Department Turnhoutseweg 30 2340 Beerse 2340 Beerse (BE)