(19)
(11) EP 2 925 774 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
07.03.2018 Bulletin 2018/10

(45) Mention of the grant of the patent:
31.01.2018 Bulletin 2018/05

(21) Application number: 13858051.9

(22) Date of filing: 26.11.2013
(51) International Patent Classification (IPC): 
C07K 14/195(2006.01)
C07K 14/39(2006.01)
A61P 31/04(2006.01)
 C07K 14/37(2006.01)
A61K 38/16(2006.01)
(86) International application number:
PCT/US2013/071941
(87) International publication number:
WO 2014/085419 (05.06.2014 Gazette 2014/23)

(54)

ENGINEERING THE PRODUCTION OF A CONFORMATIONAL VARIANT OF OCCIDIOFUNGIN THAT HAS ENHANCED INHIBITORY ACTIVITY AGAINST FUNGAL SPECIES

TECHNISCHE HERSTELLUNG EINER KONFORMATIONALEN VARIANTE VON OCCIDIOFUNGIN MIT VERBESSERTER HEMMUNGSAKTIVITÄT GEGEN PILZSPEZIES

INGÉNIERIE DE LA PRODUCTION D'UN VARIANT CONFORMATIONNEL DE L'OCCIDIOFONGINE QUI PRÉSENTE UNE ACTIVITÉ INHIBITRICE AUGMENTÉE CONTRE LES ESPÈCES FONGIQUES

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 29.11.2012 US 201261731105 P

(43) Date of publication of application:
07.10.2015 Bulletin 2015/41

(73) Proprietors:
  • The Texas A&M University System
    Bryan, Texas 77843-3369 (US)
  • Mississippi State University
    Mississippi State, MS 39762 (US)

(72) Inventors:
  • SMITH, James, Leif
    College Station, TX 77845 (US)
  • RAVICHANDRAN, Akshaya
    College Station, TX 77840 (US)
  • LU, Shein
    Starkville, MS 39759 (US)
  • GU, Ganyu
    Painter, VA 23420 (US)

(74) Representative: Dunleavy, Kevin James et al
Mendelsohn Dunleavy, P.C. p/o De Vries & Metman Overschiestraat 180
1062 XK Amsterdam
1062 XK Amsterdam (NL)


(56) References cited: : 
WO-A1-2010/138173
 US-A1- 2011 136 729
   
  • GU G ET AL: "Biosynthesis of an antifungal oligopeptide in Burkholderia contaminans strain MS14", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 380, no. 2, 6 March 2009 (2009-03-06) , pages 328-332, XP026005758, ISSN: 0006-291X, DOI: 10.1016/J.BBRC.2009.01.073 [retrieved on 2009-01-22]
  • GU, GANYU ET AL.: 'Genetic and biochemical map for the biosynthesis of occidiofungin, an antifungal produced by Burkholderia contaminans strain MS14' APPLIED AND ENVIRONMENTAL MICROBIOLOGY vol. 77, no. 17, 2011, pages 6189 - 6198, XP055256317
  • ELLIS, DAYNA ET AL.: 'Occidiofungin's chemical stability and in vitro potenc y against Candida species' ANTIMICROBIAL AGENTS AND CHEMOTHERAPY vol. 56, no. 2, 21 November 2011, pages 765 - 769, XP055256328
  • LIN, ZHENJIAN ET AL.: 'Burkholdines from Burkholderia ambifaria: antifungal agents and possible virulence factors' JOURNAL OF NATURAL PRODUCTS vol. 75, no. 9, 18 September 2012, pages 1518 - 1523, XP055256333
  • THOMSON, EUAN L. S. ET AL.: 'A Burkholderia cepacia complex non-ribosomal peptide-synthesized toxin is hemolytic and required for full virulence' VIRULENCE vol. 3, no. 3, May 2012, pages 286 - 298, XP055256342
  • DATABASE GENBANK [Online] 13 December 2010 XP055256349 Retrieved from NCBI Database accession no. ADT64850.1
  • DATABASE GENBANK [Online] 13 December 2010 XP055256358 Retrieved from NCBI Database accession no. ACL81527.1
  • RAVICHANDRAN, AKSHAYA ET AL.: 'The presence of two cyclase thioesterases expands the conformational freedom of the cyclic peptide occidiofungin' JOURNAL OF NATURAL PRODUCTS vol. 76, no. 2, 08 February 2013, pages 150 - 156, XP055256368
   
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