(19)
(11) EP 2 925 860 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
25.12.2019 Bulletin 2019/52

(45) Mention of the grant of the patent:
13.11.2019 Bulletin 2019/46

(21) Application number: 13858016.2

(22) Date of filing: 26.11.2013
(51) International Patent Classification (IPC): 
C12N 5/071(2010.01)
A61P 3/10(2006.01)
G01N 33/50(2006.01)
 A61K 35/39(2015.01)
C12N 5/073(2010.01)
(86) International application number:
PCT/US2013/072073
(87) International publication number:
WO 2014/085493 (05.06.2014 Gazette 2014/23)

(54)

METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124

VERFAHREN ZUR DIFFERENZIERUNG VON STAMMZELLEN DURCH MODULATION VON MIR-124

MÉTHODES DE DIFFÉRENCIATION DE CELLULES SOUCHES PAR MODULATION DU MIR-124

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 30.11.2012 US 201261732162 P
12.09.2013 US 201361877156 P

(43) Date of publication of application:
07.10.2015 Bulletin 2015/41

(60) Divisional application:
19188159.8

(73) Proprietor: Accelerated BioSciences Corp.
Carlsbad, California 92008 (US)

(72) Inventors:
  • LEE,Jau-Nan
    Kaohsiung Taiwan 806 (TW)
  • LEE, Tony Tung-Yin
    Yakima, WA 98903 (US)
  • LEE, Yuta
    Kaohsiung Taiwan 804 (TW)

(74) Representative: Avidity IP 
Broers Building Hauser Forum 21 JJ Thomson Avenue
Cambridge CB3 0FA
Cambridge CB3 0FA (GB)


(56) References cited: : 
EP-A1- 2 233 566
WO-A2-2006/091766
WO-A2-2012/070014
 WO-A2-03/050249
WO-A2-2012/068170
US-A1- 2011 151 560
   
  • XU, X. ET AL.: 'Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells' MECHANISMS OF DEVELOPMENT. vol. 128, no. 7-10, 2011, pages 412 - 427, XP028119959
  • JIANG, W. ET AL.: 'In vitro derivation of functional insulin-producing cells from human embryonic stem cells' CELL RESEARCH. vol. 17, 2007, pages 333 - 344, XP002455184
  • LOVIS, P. ET AL.: 'Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs' BIOLOGICAL CHEMISTRY. vol. 389, 2008, pages 305 - 312, XP008167221
  • BAROUKH, N. ET AL.: 'MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic Beta- Cell Lines' JOURNAL OF BIOLOGICAL CHEMISTRY vol. 282, no. 27, 2007, pages 19575 - 19588, XP055017783
  • LEE, T.T-Y. ET AL.: 'Ectopic pregnancy-derived human trophoblastic stem cells regenerate dopaminergic nigrostriatal pathway to treat parkinsonian rats' PLOS ONE. vol. 7, no. 12 E52, 21 December 2012, XP055107643
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).