(19)
(11) EP 2 931 712 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
23.05.2018 Bulletin 2018/21

(45) Mention of the grant of the patent:
21.03.2018 Bulletin 2018/12

(21) Application number: 13826678.8

(22) Date of filing: 13.12.2013
(51) International Patent Classification (IPC): 
C07D 241/20(2006.01)
A61P 11/12(2006.01)
 A61K 31/4965(2006.01)
(86) International application number:
PCT/US2013/075093
(87) International publication number:
WO 2014/099673 (26.06.2014 Gazette 2014/26)

(54)

3,5-DIAMINO-6-CHLORO-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZINE-2- CARBOXAMIDE COMPOUNDS

3,5-DIAMINO-6-CHLOR-N-(N-(4-PHENYLBUTYL)CARBAMIMIDOYL) PYRAZIN-2-CARBOXAMID VERBINDUNGEN

COMPOSÉS 3,5-DIAMINO-6-CHLORO-N-(N-(4-PHÉNYLBUTYL)CARBAMINIDOYL) PYRAZIN-2-CARBOXAMIDIQUES

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 17.12.2012 US 201261738235 P

(43) Date of publication of application:
21.10.2015 Bulletin 2015/43

(60) Divisional application:
18162918.9

(73) Proprietor: Parion Sciences, Inc.
Durham, NC 27713 (US)

(72) Inventor:
  • JOHNSON, Michael, R.
    Durham, NC 27713 (US)

(74) Representative: Oates, Edward Christopher et al
Carpmaels & Ransford LLP One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)


(56) References cited: : 
WO-A2-2008/031028
US-A1- 2009 082 287
 US-A1- 2006 040 954
   
  • A. J. HIRSCH ET. AL.: "Design, Synthesis and Structure-Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers. Drugs for Cystic Fibrosis and Chronic Bronchitis.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, 13 June 2006 (2006-06-13), pages 4098-4115, XP008122316, DOI: 10.1021/jm051134w
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).