(19)
(11) EP 2 931 750 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
03.11.2021 Bulletin 2021/44

(45) Mention of the grant of the patent:
29.09.2021 Bulletin 2021/39

(21) Application number: 13805897.9

(22) Date of filing: 17.12.2013
(51) International Patent Classification (IPC): 
C07K 16/24(2006.01)
(52) Cooperative Patent Classification (CPC):
C07K 2317/56; C07K 2317/76; C07K 2317/94; C07K 2317/33; C07K 2317/565; C07K 16/245; C07K 2317/24
(86) International application number:
PCT/EP2013/076831
(87) International publication number:
WO 2014/095808 (26.06.2014 Gazette 2014/26)

(54)

ANTIBODIES AGAINST IL-1 BETA

ANTIKÖRPER GEGEN IL-1 BETA

ANTICORPS DIRIGÉS CONTRE IL-1 BÉTA


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 17.12.2012 US 201261738223 P
14.02.2013 EP 13000746

(43) Date of publication of application:
21.10.2015 Bulletin 2015/43

(60) Divisional application:
21199413.2

(73) Proprietor: Cell Medica Inc.
Houston, TX 77036 (US)

(72) Inventors:
  • HONEGGER, Annemarie
    CH-8057 Zürich (CH)
  • KRETZSCHMAR, Titus
    6331 Hühnenberg (CH)
  • SCHMITT, Simone
    8953 Dietikon (CH)
  • SHAMSHIEV, Abdijapar
    CH-8053 Zürich (CH)
  • GRABULOVSKI, Stefanie
    CH-8049 Zürich (CH)

(74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB 
Leopoldstraße 4
80802 München
80802 München (DE)


(56) References cited: : 
WO-A1-2011/140522
WO-A2-2004/067568
WO-A2-2007/002261
US-A1- 2003 026 806
WO-A1-2011/140522
WO-A2-2007/002261
US-A1- 2003 026 806
   
  • ALTEN RIEKE ET AL: "The human anti-IL-1Î monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis", ARTHRITIS RESEARCH AND THERAPY, BIOMED CENTRAL, LONDON, GB, vol. 10, no. 3, 5 June 2008 (2008-06-05), page R67, XP021041234, ISSN: 1478-6354
  • Rieke Alten ET AL: "Efficacy and safety of the human anti-IL-1beta monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, phase II, dose-finding study July 2011) Background", BMC Musculoskeletal Disorders, 1 January 2011 (2011-01-01), page 153, XP055420326, Retrieved from the Internet: URL:https://www.ncbi.nlm.nih.gov/pmc/artic les/PMC3152943/pdf/1471-2474-12-153.pdf [retrieved on 2017-10-31]
  • Jianying Qi ET AL: "A bispecific antibody against IL-1&bgr; and IL-17A is beneficial for experimental rheumatoid arthritis", International Immunopharmacology, vol. 14, no. 4, 1 December 2012 (2012-12-01), pages 770-778, XP055140680, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2012.10.005
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).