(19)
(11) EP 2 931 921 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
09.01.2019 Bulletin 2019/02

(45) Mention of the grant of the patent:
31.10.2018 Bulletin 2018/44

(21) Application number: 13863040.5

(22) Date of filing: 13.12.2013
(51) International Patent Classification (IPC): 
C12Q 1/68(2018.01)
(86) International application number:
PCT/SG2013/000533
(87) International publication number:
WO 2014/092653 (19.06.2014 Gazette 2014/25)

(54)

LABEL-FREE METHODS FOR ISOLATION AND ANALYSIS OF NUCLEIC ACIDS ON SOLID PHASE DEVICE

MARKIERUNGSFREIE VERFAHREN ZUR ISOLIERUNG UND ANALYSE VON NUKLEINSÄUREN AUF EINER FESTKÖRPERVORRICHTUNG

PROCÉDÉS SANS MARQUEUR POUR L'ISOLEMENT ET L'ANALYSE D'ACIDES NUCLÉIQUES SUR DISPOSITIF EN PHASE SOLIDE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 13.12.2012 SG 201209173

(43) Date of publication of application:
21.10.2015 Bulletin 2015/43

(73) Proprietor: One Biomed Pte Ltd.
Singapore 259730 (SG)

(72) Inventors:
  • SHIN, Yong
    Singapore 117685 (SG)
  • PARK, Mi Kyoung
    Singapore 117685 (SG)

(74) Representative: Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte 
Kennedydamm 55 / Roßstrasse
40476 Düsseldorf
40476 Düsseldorf (DE)


(56) References cited: : 
   
  • YONG SHIN ET AL: "Solid phase nucleic acid extraction technique in a microfluidic chip using a novel non-chaotropic agent: dimethyl adipimidate", LAB ON A CHIP: MINIATURISATION FOR CHEMISTRY, PHYSICS, BIOLOGY, MATERIALS SCIENCE AND BIOENGINEERING, vol. 14, no. 2, 22 November 2013 (2013-11-22), pages 359-368, XP055261226, GB ISSN: 1473-0197, DOI: 10.1039/C3LC51035B
  • SUTER J D ET AL: "Label-free DNA methylation analysis using opto-fluidic ring resonators", BIOSENSORS AND BIOELECTRONICS, ELSEVIER BV, NL, vol. 26, no. 3, 15 November 2010 (2010-11-15), pages 1016-1020, XP027393251, ISSN: 0956-5663 [retrieved on 2010-08-20]
  • SUTER, J.D. ET AL.: 'Label-free DNA methylation analysis using opto-fluidic ring resonators' BIOSENSORS AND BIOELECTRONICS vol. 26, no. 3, 15 November 2010, pages 1016 - 1020, XP027393251 DOI: 10.1016/J.BIOS.2010.08.050
  • SHIN, Y. ET AL.: 'SOLID PHASE NUCLEIC ACID EXTRACTION TECHNIQUE IN A MICROFLUIDIC CHIP USING A NOVEL NON-CHAOTROPIC AGENT: DIMETHYL ADIPIMIDATE' LAB ON A CHIP vol. 14, no. 2, 01 January 2014, pages 359 - 368, XP055261226 DOI: 10.1039/C3LC51035B
   
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