(19)
(11) EP 2 949 644 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
20.04.2016 Bulletin 2016/16

(43) Date of publication A2:
02.12.2015 Bulletin 2015/49

(21) Application number: 15165987.7

(22) Date of filing: 25.10.2005
(51) International Patent Classification (IPC): 
C07C 237/26(2006.01)
C07D 295/155(2006.01)
A61P 31/04(2006.01)
A61P 33/00(2006.01)
 C07D 211/34(2006.01)
A61K 31/65(2006.01)
A61P 31/12(2006.01)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

(30) Priority: 25.10.2004 US 622027 P
27.10.2004 US 622749 P

(62) Application number of the earlier application in accordance with Art. 76 EPC:
10182880.4 / 2269985
05824836.0 / 1807387

(71) Applicant: Paratek Pharmaceuticals, Inc.
Boston, MA 02111 (US)

(72) Inventors:
  • Abato, Paul
    Providence, RI 02906 (US)
  • Assefa, Haregewein
    Braintree, MA 02184 (US)
  • Berniac, Joel
    Stoneham, MA 02180 (US)
  • Bowser, Todd
    Charlton, MA 01507 (US)
  • Bhatia, Beena
    Mansfield, MA 02048 (US)
  • Chen, Jackson
    East Amberst, NY 14051 (US)
  • Grier, Mark
    Watertown, MA 02472 (US)
  • Honeyman, Laura
    Roslindale, MA 02131 (US)
  • Ismail, Mohammed, Y.
    Bedford, MA 01730 (US)
  • Nelson, Mark
    Norfolk, MA 02056 (US)
  • Kwasi, Ohemeng
    Tema (GH)
  • Pan, Jingwen
    North Grafton, MA 01536 (US)

(74) Representative: Johnston, Magnus George 
Haseltine Lake LLP Redcliff Quay 120 Redcliff Street
Bristol BS1 6HU
Bristol BS1 6HU (GB)

   


(54) SUBSTITUTED TETRACYCLINE COMPOUNDS


(57) The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.





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