(19)
(11) EP 2 949 747 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
04.10.2017 Bulletin 2017/40

(45) Mention of the grant of the patent:
09.08.2017 Bulletin 2017/32

(21) Application number: 14743709.9

(22) Date of filing: 24.01.2014
(51) International Patent Classification (IPC): 
C12N 5/071(2010.01)
C12N 5/0775(2010.01)
 A61L 27/00(2006.01)
(86) International application number:
PCT/JP2014/000372
(87) International publication number:
WO 2014/115562 (31.07.2014 Gazette 2014/31)

(54)

CREATION OF THREE-DIMENSIONAL SYNTHETIC TISSUE FROM PLURIPOTENT STEM CELL-DERIVED CELLS, AND OSTEOCHONDRAL REGENERATION TREATMENT USING SAID SYNTHETIC TISSUE

ERZEUGUNG VON DREIDIMENSIONALEM KÜNSTLICHEM GEWEBE AUS VON PLURIPOTENTEN STAMMZELLEN ABGELEITETEN ZELLEN UND BEHANDLUNG FÜR OSTEOCHONDRALE REGENERATION MITHILFE DES KÜNSTLICHEN GEWEBES

CRÉATION DE TISSU ARTIFICIEL TRIDIMENSIONNEL À PARTIR DE CELLULES DÉRIVÉES DE CELLULES SOUCHES PLURIPOTENTES ET TRAITEMENT DE RÉGÉNÉRATION OSTÉOCHONDRALE UTILISANT LEDIT TISSU ARTIFICIEL

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 25.01.2013 JP 2013012630

(43) Date of publication of application:
02.12.2015 Bulletin 2015/49

(73) Proprietor: Osaka University
Suita-shi, Osaka 565-0871 (JP)

(72) Inventors:
  • YOSHIKAWA,Hideki
    Suita-shi Osaka 565-0871 (JP)
  • NAKAMURA, Norimasa
    Suita-shi Osaka 565-0871 (JP)
  • SHIMOMURA, Kazunori
    Suita-shi Osaka 565-0871 (JP)
  • MORIGUCHI, Yu
    Suita-shi Osaka 565-0871 (JP)
  • CHIJIMATSU, Ryota
    Suita-shi Osaka 565-0871 (JP)
  • YASUI, Yukihiko
    Suita-shi Osaka 565-0871 (JP)

(74) Representative: Uexküll & Stolberg 
Partnerschaft von Patent- und Rechtsanwälten mbB Beselerstraße 4
22607 Hamburg
22607 Hamburg (DE)


(56) References cited: : 
EP-A1- 2 799 093
JP-A- 2007 528 756
 EP-B1- 1 651 756
   
  • YU MORIGUCHI ET AL.: 'Usagi Haisei Kansaibo yori Yudo sareta Kan'yokei Kansaibo Yurai Scaffold Free Sanjigen Jinko Soshiki no Keisei to sono Nankotsu Bunka Yudo' THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION vol. 85, no. 8, 2011, pages S1267, 2 - 6-29, XP008180151
  • BUCKLEY C.T. ET AL.: 'Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs' JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS vol. 11, 01 June 2012, pages 102 - 111, XP028926491 DOI: 10.1016/j.jmbbm.2011.09.004
  • AZOUNA NESRINE BEN ET AL.: 'Phenotypical and functional characteristics of mesenchymal stem cells from bone marrow: comparison of culture using different media supplemented with human platelet lysate or fetal bovine serum' STEM CELL RESEARCH & THERAPY vol. 3, 01 January 2012, pages 1 - 14, XP021117611 DOI: 10.1186/scrt97
  • TAKESHI TERAMURA ET AL.: 'Teisanso Baiyo ni yoru Usagi ES Saibo kara no Kan'yokei Kansaibo no Bunka Yudo' REGENERATIVE MEDICI NE vol. 11, 2012, pages 233, B-1 - 51, XP008181709
  • LEE SANG-HWA ET AL.: 'Culture of Mesenchymal Stromal Cells from Dental Pulp: Culture Medium Study for Effective Expansion and Characterization' TISSUE ENGINEERING AND REGENERATIVE MEDICINE vol. 7, no. 2, 2010, pages 248 - 254, XP008181633
  • CRAMER CHRISTOPHER ET AL.: 'Persistent High Glucose Concentrations Alter the Regenerative Potential of Mesenchymal Stem Cells' STEM CELLS AND DEVELOPMENT vol. 19, no. 12, 01 January 2010, pages 1875 - 1884, XP055266731 DOI: 10.1089/scd.2010.0009
  • HWANG NATHANIEL S. ET AL.: 'In vivo commitment and functional tissue regeneration using human embryonic stem cell -derived mesenchymal cells' PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES vol. 105, no. 52, 30 December 2008, pages 20641 - 20646, XP055266736 DOI: 10.1073/pnas.0809680106
   
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