(19)

(11)

EP 2 956 132 A1

(12)

(43) Date of publication: 23.12.2015 Bulletin 2015/52 (21) Application number: 13839774.0 (22) Date of filing: 20.09.2013

(51) International Patent Classification (IPC):  A61K 31/352(2006.01) A61K 31/495(2006.01) A61P 35/00(2006.01) A61K 31/437(2006.01) A61K 31/5025(2006.01) (86) International application number: PCT/US2013/060842 (87) International publication number: WO 2014/047398 (27.03.2014 Gazette 2014/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 21.09.2012 US 201261704033 P (71) Applicants: The General Hospital Corporation Boston, MA 02114 (US) Ramaswamy, Sridhar Wellesley, Massachusetts 02482 (US)	(72) Inventor: RAMASWAMY, Sridhar Wellesley, Massachusetts 02482 (US) (74) Representative: Brown, David Leslie  Haseltine Lake LLP Redcliff Quay 120 Redcliff Street Bristol BS1 6HU Bristol BS1 6HU (GB)