(19)
(11) EP 2 961 750 A1

(12)

(43) Date of publication:
06.01.2016 Bulletin 2016/01

(21) Application number: 14710724.7

(22) Date of filing: 27.02.2014
(51) International Patent Classification (IPC): 
C07D 471/04(2006.01)
A61P 35/00(2006.01)
 A61K 31/519(2006.01)
(86) International application number:
PCT/US2014/019030
(87) International publication number:
WO 2014/134308 (04.09.2014 Gazette 2014/36)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 01.03.2013 US 201361771582 P
05.11.2013 US 201361900156 P

(71) Applicant: Amgen Inc.
Thousand Oaks, California 91320 (US)

(72) Inventors:
  • WURZ, Ryan
    Newbury Park, California 91320 (US)
  • TASKER, Andrew
    Simi Valley, California 93065 (US)
  • TADESSE, Seifu
    Simi Valley, California 93065 (US)
  • PETTUS, Liping H.
    Thousand Oaks, California 91360 (US)
  • NGUYEN, Thomas T.
    Newbury Park, California 91320 (US)
  • HONG, Fang-Tsao
    Thousand Oaks, California 91360 (US)
  • HERBERICH, Bradley J.
    Newbury Park, California 91320 (US)
  • HARRINGTON, Essa
    Camarillo, California 93012 (US)
  • CHEN, Jian J.
    Camarillo, California 93012 (US)
  • BROWN, James
    Moorpark, California 93021 (US)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)

   


(54) SUBSTITUTED 7-OXO-PYRIDO [2, 3-D]PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF EGFR / ERBB2 RELATED DISORDERS