(19)

(11)

EP 2 961 837 A2

(12)

(88) Date of publication A3: 13.11.2014 (43) Date of publication: 06.01.2016 Bulletin 2016/01 (21) Application number: 14709381.9 (22) Date of filing: 27.02.2014

(51) International Patent Classification (IPC):  C12N 9/02(2006.01) C12N 9/10(2006.01) C12N 9/90(2006.01) C07K 14/32(2006.01) C12N 9/88(2006.01) C12N 9/00(2006.01) (86) International application number: PCT/GB2014/050584 (87) International publication number: WO 2014/132064 (04.09.2014 Gazette 2014/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 27.02.2013 GB 201303474 (71) Applicant: University of Newcastle Upon Tyne Newcastle Upon Tyne NE1 7RU (GB)	(72) Inventors: ERRINGTON, Jeff Newcastle upon Tyne Tyne and Wear NE1 7RU (GB) KAWAI, Yoshikazu Newcastle upon Tyne Tyne and Wear NE1 7RU (GB) MERCIER, Roman Newcastle upon Tyne Tyne and Wear NE1 7RU (GB) (74) Representative: Lubben, Nienke  HGF Limited Saviour House 9 St Saviourgate York YO1 8NQ York YO1 8NQ (GB)