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EP 2 961 841 A1

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(43) Date of publication: 06.01.2016 Bulletin 2016/01 (21) Application number: 14757511.2 (22) Date of filing: 03.03.2014

(51) International Patent Classification (IPC):  C12N 15/09(2006.01) A61K 48/00(2006.01) A61K 31/7088(2006.01) A61P 43/00(2006.01) (86) International application number: PCT/JP2014/001159 (87) International publication number: WO 2014/132671 (04.09.2014 Gazette 2014/36)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 01.03.2013 US 201361771115 P 31.03.2013 US 201361806887 P 26.11.2013 US 201361909179 P (71) Applicant: National University Corporation Tokyo Medical and Dental University Bunkyo-ku Tokyo 113-8510 (JP)

(72) Inventors: YOKOTA, Takanori Tokyo 113-8510 (JP) NISHINA, Kazutaka Tokyo 113-8510 (JP) MIZUSAWA, Hidehiro Tokyo 113-8510 (JP) WADA, Takeshi Tokyo 113-8510 (JP) (74) Representative: Denison, Christopher Marcus et al Mewburn Ellis LLP City Tower 40 Basinghall Street London EC2V 5DE City Tower 40 Basinghall Street London EC2V 5DE (GB)