(19)

(11)

EP 2 968 295 A1

(12)

(43) Date of publication: 20.01.2016 Bulletin 2016/03 (21) Application number: 14768961.6 (22) Date of filing: 10.03.2014

(51) International Patent Classification (IPC):  A61K 31/4427(2006.01) A61K 31/444(2006.01) A61K 31/4439(2006.01) A61P 7/00(2006.01) (86) International application number: PCT/US2014/022733 (87) International publication number: WO 2014/150256 (25.09.2014 Gazette 2014/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 15.03.2013 US 201313815872 31.07.2013 US 201361860793 P (71) Applicant: Global Blood Therapeutics, Inc. South San Francisco, CA 94080 (US)	(72) Inventors: SINHA, Uma South San Francisco, CA 94080 (US) METCALF, Brian, W. South San Francisco, CA 94080 (US) OKSENBERG, Donna South San Francisco, CA 94080 (US) DUFU, Kobina, N. South San Francisco, CA 94080 (US) PATEL, Mira, P. South San Francisco, CA 94080 (US) (74) Representative: Carpmaels & Ransford LLP  One Southampton Row London WC1B 5HA London WC1B 5HA (GB)