(19)

(11)

EP 2 968 317 A1

(12)

(43) Date of publication: 20.01.2016 Bulletin 2016/03 (21) Application number: 14762460.5 (22) Date of filing: 17.03.2014

(51) International Patent Classification (IPC):  A61K 31/497(2006.01) C07D 471/04(2006.01) A61K 31/519(2006.01) (86) International application number: PCT/US2014/030693 (87) International publication number: WO 2014/145857 (18.09.2014 Gazette 2014/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 15.03.2013 US 201361794606 P 15.03.2013 US 201361852150 P 21.03.2013 US 201361803977 P 19.12.2013 US 201361918307 P (71) Applicant: The Trustees of Columbia University in the City of New York New York, New York 10027 (US)

(72) Inventors: KARAYIORGOU, Maria Riverdale, NY 10471 (US) MARKX, Sander Brooklyn, NY 11201 (US) GOGOS, Joseph, A. Riverdale, NY 10471 (US) (74) Representative: Atkinson, Jennifer  Barker Brettell LLP 100 Hagley Road Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB)