(19)

(11)

EP 2 968 539 A1

(12)

(43) Date of publication: 20.01.2016 Bulletin 2016/03 (21) Application number: 14722878.7 (22) Date of filing: 14.03.2014

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) A61K 31/506(2006.01) A61P 35/00(2006.01) A61K 45/06(2006.01) A61K 31/519(2006.01) A61P 35/02(2006.01) (86) International application number: PCT/US2014/027977 (87) International publication number: WO 2014/143835 (18.09.2014 Gazette 2014/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 15.03.2013 US 201361794168 P 20.09.2013 US 201361880585 P (71) Applicant: Memorial Sloan Kettering Cancer Center New York, NY 10021 (US)	(72) Inventors: SCHEINBERG, David New York, NY 10025 (US) DUBROVSKY, Leonid New York, NY 10065 (US) (74) Representative: Chapman, Desmond Mark  Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA London WC1B 5HA (GB)