(19)

(11)

EP 2 968 609 A2

(12)

(88) Date of publication A3: 06.11.2014 (43) Date of publication: 20.01.2016 Bulletin 2016/03 (21) Application number: 14765183.0 (22) Date of filing: 14.03.2014

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) (86) International application number: PCT/US2014/029386 (87) International publication number: WO 2014/144815 (18.09.2014 Gazette 2014/38)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 15.03.2013 US 201313844138 30.08.2013 WO PCT/US2013/057721 (71) Applicants: The Regents of the University of California Oakland, CA 94607 (US) Nolta, Jan Davis, CA 95616 (US) Pepper, Karen Davis, CA 95616 (US) Fierro, Fernando Davis, CA 95616 (US) Bauer, Gerhard Davis, CA 95616 (US)

(72) Inventors: NOLTA, Jan Davis, CA 95616 (US) PEPPER, Karen Davis, CA 95616 (US) FIERRO, Fernando Davis, CA 95616 (US) BAUER, Gerhard Davis, CA 95616 (US) (74) Representative: Gates, Marie Christina Esther et al Tomkins & Co. 5 Dartmouth Road Dublin 6 Dublin 6 (IE)