EUTECTIC FORMULATIONS OF CYCLOBENZAPRINE HYDROCHLORIDE AND MANNITOL

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EP 2 968 992 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	15.01.2020 Bulletin 2020/03

(45)	Mention of the grant of the patent:
	11.12.2019 Bulletin 2019/50

(21)	Application number: 14762323.5

(22)	Date of filing: 14.03.2014

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International Patent Classification (IPC):

A61P 21/02^(2006.01)
A61K 9/16^(2006.01)
A61P 43/00^(2006.01)

A61K 9/14^(2006.01)
A61K 31/135^(2006.01)

(86)	International application number:
	PCT/US2014/029872

(87)	International publication number:
	WO 2014/145156 (18.09.2014 Gazette 2014/38)

(54)	EUTECTIC FORMULATIONS OF CYCLOBENZAPRINE HYDROCHLORIDE AND MANNITOL EUTEKTISCHE FORMULIERUNGEN AUS CYCLOBENZAPRIN-HYDROCHLORID UND MANNITOL FORMULATIONS EUTECTIQUES DE CHLORHYDRATE DE CYCLOBENZAPRINE ET DE MANNITOL

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

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Priority:

15.03.2013 US 201361792757 P

(43)	Date of publication of application:
	20.01.2016 Bulletin 2016/03

(60)	Divisional application:
	19214535.7

(73)	Proprietor: Tonix Pharma Holdings Limited
	Hamilton HM 10 (BM)

(72)	Inventors:
	NEBULONI, Marino I-20017 Rho (MI) (IT) COLOMBO, Patrizia I-20090 Trezzano sul Naviglio (IT)

(74)	Representative: Garner, Stephen et al
	Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG London SE1 9SG (GB)

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References cited: :

EP-A1- 2 233 134
US-A1- 2005 181 041
US-A1- 2008 146 672
US-A1- 2010 021 507

US-A1- 2003 077 297
US-A1- 2007 141 144
US-A1- 2009 098 200

DATABASE EMBASE [Online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1985, FORD J L ET AL: "Thermal analysis of sulphamethoxazole - Sugar physical mixes", XP002760058, Database accession no. EMB-1985192963 & FORD J L ET AL: "Thermal analysis of sulphamethoxazole - Sugar physical mixes", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 1985 US, vol. 11, no. 5, 1985, pages 1111-1122, ISSN: 0363-9045
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1975, EL-BANNA H M ET AL: "PHYSICOCHEMICAL STUDY OF DRUG BINARY SYSTEMS PART 3 TOLBUTAMIDE UREA AND TOLBUTAMIDE MANNITOL SYSTEMS", XP002760059, Database accession no. PREV197662039091 & EL-BANNA H M ET AL: "PHYSICOCHEMICAL STUDY OF DRUG BINARY SYSTEMS PART 3 TOLBUTAMIDE UREA AND TOLBUTAMIDE MANNITOL SYSTEMS", DIE PHARMAZIE, vol. 30, no. 12, 1975, pages 788-792, ISSN: 0031-7144

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).