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EP 2 970 223 A1

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(43) Date of publication: 20.01.2016 Bulletin 2016/03 (21) Application number: 14779591.8 (22) Date of filing: 11.03.2014

(51) International Patent Classification (IPC):  C07D 405/06(2006.01) C07D 403/06(2006.01) A61K 31/443(2006.01) A61P 25/18(2006.01) A61P 25/28(2006.01) A61P 3/00(2006.01) C07D 401/06(2006.01) A61K 31/34(2006.01) A61K 31/497(2006.01) A61P 25/24(2006.01) A61P 9/12(2006.01) (86) International application number: PCT/US2014/023400 (87) International publication number: WO 2014/164756 (09.10.2014 Gazette 2014/41)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 11.03.2013 US 201361776117 P (71) Applicant: Temple University Of The Commonwealth System Of Higher Education Philadelphia, PA 19122-6029 (US)	(72) Inventors: CANNEY, Daniel, J. Ambler, PA 19002 (US) BLASS, Benjamin, E. Eagleville, PA 19403 (US) GAO, Rong Eugene, OR 97402 (US) ABOU-GHARBIA, Magid Exton, PA 19341 (US) (74) Representative: Patentanwälte Ruff, Wilhelm, Beier, Dauster & Partner mbB  Kronenstraße 30 70174 Stuttgart 70174 Stuttgart (DE)