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EP 2 970 302 A1

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(43) Date of publication: 20.01.2016 Bulletin 2016/03 (21) Application number: 14721638.6 (22) Date of filing: 14.03.2014

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61K 31/4985(2006.01) A61P 25/00(2006.01) A61P 35/00(2006.01) C07D 519/00(2006.01) A61K 31/551(2006.01) A61P 29/00(2006.01) (86) International application number: PCT/US2014/027664 (87) International publication number: WO 2014/152725 (25.09.2014 Gazette 2014/39)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 15.03.2013 US 201361790281 P (71) Applicant: Biogen MA Inc. Cambridge, MA 02142 (US)

(72) Inventors: PENG, Hairuo Cambridge, MA 02142 (US) XIN, Zhili Cambridge, MA 02142 (US) ZHANG, Lei Cambridge, MA 02142 (US) SUN, Lihong Cambridge, MA 02142 (US) KUMARAVEL, Gnanasambandam Cambridge, MA 02142 (US) TAVERAS, Art Cambridge, MA 02142 (US) WANG, Deping Cambridge, MA 02142 (US) (74) Representative: Wells, Andrew  HGF Limited 4th Floor, Merchant Exchange 17-19 Whitworth Street West Manchester M1 5WG Manchester M1 5WG (GB)