(19)

(11)

EP 2 970 432 A1

(12)

(43) Date of publication: 20.01.2016 Bulletin 2016/03 (21) Application number: 14773793.6 (22) Date of filing: 12.03.2014

(51) International Patent Classification (IPC):  C07K 14/78(2006.01) C12N 5/095(2010.01) C12N 5/09(2010.01) C12Q 1/02(2006.01) (86) International application number: PCT/US2014/024847 (87) International publication number: WO 2014/159707 (02.10.2014 Gazette 2014/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 14.03.2013 US 201313827170 (71) Applicants: Hackensack University Medical Center Hackensack, NJ 07601 (US) The Trustees Of The Stevens Institute Of Technology Hoboken, New Jersey 07030 (US)	(72) Inventors: LEE, Woo Ridgewood, NJ 07450 (US) ZHANG, Wenting Jersey City, NJ 07307 (US) TOLIAS, Peter Westfield, NJ 07090 (US) WANG, Hongjun Millburn, NJ 07041 (US) ZILBERBERG, Jenny Yardley, PA 19067 (US) SIEGEL, David, Samuel West Orange, NJ 07052 (US) (74) Representative: Wright, Simon Mark  J A Kemp 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)