(19)
(11) EP 2 970 731 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
13.05.2020 Bulletin 2020/20

(45) Mention of the grant of the patent:
04.09.2019 Bulletin 2019/36

(21) Application number: 14773437.0

(22) Date of filing: 13.03.2014
(51) International Patent Classification (IPC): 
C09K 3/00(2006.01)
A61L 24/00(2006.01)
(86) International application number:
PCT/US2014/025896
(87) International publication number:
WO 2014/160136 (02.10.2014 Gazette 2014/40)

(54)

ADVANCED FUNCTIONAL BIOCOMPATIBLE POLYMER PUTTY USED AS A HEMOSTATIC AGENT FOR TREATING DAMAGED TISSUE AND CELLS

VERBESSERTER KITT AUS FUNKTIONELLEM BIOKOMPATIBLEM POLYMER ALS HÄMOSTYPTIKUM ZUR BEHANDLUNG VON GESCHÄDIGTEM GEWEBE UND ZELLEN

PÂTE POLYMÈRE BIOCOMPATIBLE FONCTIONNELLE AVANCÉE UTILISÉE COMME AGENT HÉMOSTATIQUE POUR LE TRAITEMENT DE TISSU ET DE CELLULES ENDOMMAGÉS


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 13.03.2013 US 201361779706 P

(43) Date of publication of application:
20.01.2016 Bulletin 2016/03

(60) Divisional application:
19195123.5 / 3599264

(73) Proprietor: The University of Maryland, College Park
College Park, Maryland 20742 (US)

(72) Inventors:
  • DIEHN, Kevin
    Towson, Maryland 21286 (US)
  • DOWLING, Matthew
    College Park, Maryland 20742 (US)
  • RAGHAVAN, Srinivasa R.
    Silver Spring, Maryland 20904 (US)
  • KING, David R.
    Cambridge, Maryland 02114 (US)

(74) Representative: FRKelly 
27 Clyde Road
Dublin D04 F838
Dublin D04 F838 (IE)


(56) References cited: : 
WO-A1-2009/037500
US-A1- 2007 148 215
US-A1- 2012 058 970
US-A1- 2002 042 473
US-A1- 2011 280 857
   
  • LIANG S ET AL: "Preparation of single or double-network chitosan/poly(vinyl alcohol) gel films through selectively cross-linking method", CARBOHYDRATE POLYMERS, APPLIED SCIENCE PUBLISHERS, LTD. BARKING, GB, vol. 77, no. 4, 19 July 2009 (2009-07-19), pages 718-724, XP026130488, ISSN: 0144-8617, DOI: 10.1016/J.CARBPOL.2009.02.007 [retrieved on 2009-02-24]
  • UTTAM MANNA ET AL: "Borax Mediated Layer-by-Layer Self-Assembly of Neutral Poly(vinyl alcohol) and Chitosan", JOURNAL OF PHYSICAL CHEMISTRY PART B: CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL, vol. 113, no. 27, 9 July 2009 (2009-07-09) , pages 9137-9142, XP055308557, US ISSN: 1520-6106, DOI: 10.1021/jp9025333
  • JAE-HO LEE ET AL: "Biopolymer-Connected Liposome Networks as Injectable Biomaterials Capable of Sustained Local Drug Delivery", BIOMACROMOLECULES, vol. 13, no. 10, 8 October 2012 (2012-10-08), pages 3388-3394, XP055308568, US ISSN: 1525-7797, DOI: 10.1021/bm301143d
  • MATTHEW B DOWLING ET AL: "A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 32, no. 13, 22 December 2010 (2010-12-22), pages 3351-3357, XP028366478, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2010.12.033 [retrieved on 2010-12-29]
  • YANJUN CHEN ET AL: "Gelation of Vesicles and Nanoparticles Using Water-Soluble Hydrophobically Modified Chitosan", LANGMUIR, vol. 29, no. 49, 10 December 2013 (2013-12-10), pages 15302-15308, XP055308576, US ISSN: 0743-7463, DOI: 10.1021/la4037343
  • Refika Yildiz: "DOKUZ EYLÜL UNIVERSITY GRADUATE SCHOOL OF NATURAL AND APPLIED SCIENCES PREPARATION AND CHARACTERIZATION OF POLY(VINYL ALCOHOL)-BORATE/CHITOSAN FILMS", , 1 June 2013 (2013-06-01), pages 1-35, XP055308883, Retrieved from the Internet: URL:http://acikerisim.deu.edu.tr/xmlui/bit stream/handle/12345/7638/343023.pdf?sequen ce=1&isAllowed=y [retrieved on 2016-10-10]
  • Paul A. Mccarron ET AL: "Preliminary Clinical Assessment of Polyvinyl Alcohol-Tetrahydroxyborate Hydrogels as Potential Topical Formulations for Local Anesthesia of Lacerations : TOPICAL ANAESTHESIA USING PVA HYDROGELS", ACADEMIC EMERGENCY MEDICINE, vol. 18, no. 4, 15 April 2011 (2011-04-15) , pages 333-339, XP055377946, US ISSN: 1069-6563, DOI: 10.1111/j.1553-2712.2011.01032.x
  • IGNATOVA M ET AL: "Electrospun nano-fibre mats with antibacterial properties from quaternised chitosan and poly(vinyl alcohol)", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 341, no. 12, 4 September 2006 (2006-09-04), pages 2098-2107, XP025010426, ISSN: 0008-6215, DOI: 10.1016/J.CARRES.2006.05.006 [retrieved on 2006-09-04]
  • Gerard P. De Castro ET AL: "Determination of efficacy of novel modified chitosan sponge dressing in a lethal arterial injury model in swine :", JOURNAL OF TRAUMA, vol. 72, no. 4, 1 April 2012 (2012-04-01), pages 899-907, XP55377950, US ISSN: 0022-5282, DOI: 10.1097/TA.0b013e318248baa1
   
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