(19)
(11) EP 2 970 883 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
23.06.2021 Bulletin 2021/25

(45) Mention of the grant of the patent:
05.05.2021 Bulletin 2021/18

(21) Application number: 14773405.7

(22) Date of filing: 13.03.2014
(51) International Patent Classification (IPC): 
C12N 5/00(2006.01)
 C12N 5/02(2006.01)
(86) International application number:
PCT/US2014/025202
(87) International publication number:
WO 2014/159806 (02.10.2014 Gazette 2014/40)

(54)

ENHANCED PLACENTAL STEM CELLS AND USES THEREOF

VERBESSERTE PLAZENTASTAMMZELLEN UND VERWENDUNGEN DAVON

CELLULES SOUCHES PLACENTAIRES AMÉLIORÉES ET LEURS UTILISATIONS

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 14.03.2013 US 201361785222 P

(43) Date of publication of application:
20.01.2016 Bulletin 2016/03

(60) Divisional application:
21158243.2

(73) Proprietor: Celularity Inc.
Florham Park, NJ 07932 (US)

(72) Inventors:
  • ABBOT, Stewart
    Warren, NJ 07059 (US)
  • KARASIEWICZ-MENDEZ, Kathy
    Hillsborough, NJ 08844 (US)
  • ZHANG, Xiaokui
    Livingston, NJ 07039 (US)

(74) Representative: Mewburn Ellis LLP 
Aurora Building Counterslip
Bristol BS1 6BX
Bristol BS1 6BX (GB)


(56) References cited: : 
WO-A1-2014/093753
US-A1- 2006 099 194
 WO-A2-2005/001076
US-A1- 2012 230 959
   
  • YAPING WANG ET AL: "miR-16 inhibits the proliferation and angiogenesis-regulating potential of mesenchymal stem cells in severe pre-eclampsia", FEBS JOURNAL, vol. 279, no. 24, 22 November 2012 (2012-11-22), pages 4510-4524, XP055310688, GB ISSN: 1742-464X, DOI: 10.1111/febs.12037
  • SHENG-HUA ZHOU: "Mesenchymal stem cells modified with miR-126 release angiogenic factors and activate Notch ligand Delta-like-4, enhancing ischemic angiogenesis and cell survival", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 3 December 2012 (2012-12-03), XP055310694, GR ISSN: 1107-3756, DOI: 10.3892/ijmm.2012.1200
  • YU NIE ET AL: "Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 1 January 2011 (2011-01-01), pages 762-768, XP055204995, ISSN: 1449-2288, DOI: 10.7150/ijbs.7.762
  • ALEXANDER RUDOV ET AL: "Involvement of miRNAs in Placental Alterations Mediated by Oxidative Stress", OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, vol. 19, no. 1-2, 1 January 2014 (2014-01-01), pages 544-7, XP055310691, US ISSN: 1942-0900, DOI: 10.1095/biolreprod.108.075481
  • WANG, YY ET AL.: 'Bcl2 Enhances Induced Hematopoietic Differentiation Of Murine Embryonic Stem Cells.' EXPERIMENTAL HEMATOLOGY. vol. 36, no. 2, 26 November 2008, pages 128 - 139, XP022425429 DOI: 10.1016/J.EXPHEM.2007.09.004
  • Afshin Samali ET AL: "Cell Stress and Cell Death", International Journal of Cell Biology, vol. 2010, 1 January 2010 (2010-01-01), pages 1-2, XP055384465, US ISSN: 1687-8876, DOI: 10.1155/2010/245803
  • YONGZHAO ZHU ET AL: "Placental mesenchymal stem cells of fetal and maternal origins demonstrate different therapeutic potentials", STEM CELL RESEARCH & THERAPY, BIOMED CENTRAL LTD, LONDON, UK, vol. 5, no. 2, 10 April 2014 (2014-04-10), page 48, XP021185529, ISSN: 1757-6512, DOI: 10.1186/SCRT436
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).