(19)
(11) EP 2 971 033 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
10.07.2019 Bulletin 2019/28

(45) Mention of the grant of the patent:
29.05.2019 Bulletin 2019/22

(21) Application number: 14769839.3

(22) Date of filing: 13.03.2014
(51) International Patent Classification (IPC): 
C12N 15/10(2006.01)
 C12P 19/34(2006.01)
(86) International application number:
PCT/US2014/026835
(87) International publication number:
WO 2014/152027 (25.09.2014 Gazette 2014/39)

(54)

MANUFACTURING METHODS FOR PRODUCTION OF RNA TRANSCRIPTS

HERSTELLUNGSVERFAHREN ZUR HERSTELLUNG VON RNA-TRANSKRIPTEN

PROCÉDÉS DE FABRICATION POUR LA PRODUCTION DE TRANSCRITS D'ARN

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 15.03.2013 US 201361800049 P

(43) Date of publication of application:
20.01.2016 Bulletin 2016/03

(60) Divisional application:
19171552.3

(73) Proprietor: ModernaTX, Inc.
Cambridge, MA 02141 (US)

(72) Inventors:
  • BANCEL, Stephane
    Cambridge, MA 02141 (US)
  • ISSA, William, Joseph
    Cambridge, MA 02139 (US)
  • AUNINS, John, Grant
    Cambridge, MA 02139 (US)
  • CHAKRABORTY, Tirtha
    Cambridge, MA 02139 (US)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)


(56) References cited: : 
WO-A1-91/05058
WO-A1-2014/152030
WO-A2-2007/120863
WO-A2-2009/149253
WO-A2-2014/113089
US-B1- 6 511 832
 WO-A1-2008/039669
WO-A2-02/44399
WO-A2-2008/083949
WO-A2-2014/028429
US-A1- 2004 259 097
US-B2- 8 093 367
   
  • PASCOLO S: "Vaccination with messenger RNA", METHODS IN MOLECULAR MEDICINE,, 1 January 2006 (2006-01-01), pages 23-40, XP009117840, ISSN: 1543-1894
  • WEISS RICHARD ET AL: "Prophylactic mRNA vaccination against allergy", CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, LIPPINCOTT WILLIAMS AND WILKINS, US, vol. 10, no. 6, 1 December 2010 (2010-12-01), pages 567-574, XP009164452, ISSN: 1528-4050, DOI: 10.1097/ACI.0B013E32833FD5B6
  • VOMELOVA I ET AL: "Methods of RNA Purification. All Ways (Should) Lead to Rome", FOLIA BIOLOGICA (PRAHA),, vol. 55, no. 6, 1 January 2009 (2009-01-01), pages 243-251, XP002724956, ISSN: 0015-5500
  • Saumya Bhaduri ET AL: "Procedure for the Preparation of Milligram Quantities of Adenovirus Messenger Ribonucleic Acid", JOURNAL OF VIROLOGY., vol. 10, no. 6, 1 December 1972 (1972-12-01), pages 1126-1129, XP055232582, US ISSN: 0022-538X
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).