(19)
(11) EP 2 988 785 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
04.04.2018 Bulletin 2018/14

(45) Mention of the grant of the patent:
01.11.2017 Bulletin 2017/44

(21) Application number: 14726715.7

(22) Date of filing: 25.04.2014
(51) International Patent Classification (IPC): 
A61K 47/68(2017.01)
(86) International application number:
PCT/GB2014/051304
(87) International publication number:
WO 2014/174316 (30.10.2014 Gazette 2014/44)

(54)

METHOD OF SYNTHESISING ADCS USING AFFINITY RESINS

VERFAHREN ZUR SYNTHESE VON ADCS MITHILFE VON AFFINITÄTSHARZEN

PROCÉDÉ DE SYNTHÈSE DE CONJUGUÉS ANTICORPS-MÉDICAMENT AU MOYEN DE RÉSINES D'AFFINITÉ


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 26.04.2013 GB 201307574

(43) Date of publication of application:
02.03.2016 Bulletin 2016/09

(73) Proprietor: Adc Biotechnology Ltd
St. Asaph, Denbighshire LL17 0JD (GB)

(72) Inventors:
  • EVANS, David John
    Chester CH3 5RW (GB)
  • MCKEE, Colin Martin
    Conwy LL32 8GU (GB)

(74) Representative: HGF Limited 
1 City Walk
Leeds LS11 9DX
Leeds LS11 9DX (GB)


(56) References cited: : 
WO-A1-2004/035199
WO-A1-2012/140433
US-A1- 2005 276 812
WO-A1-2011/109308
WO-A1-2012/163805
US-A1- 2011 046 353
   
  • CECILIA A ROQUE A ET AL: "Antibodies and Genetically Engineered Related Molecules: Production and Purification", BIOTECHNOLOGY PROGRESS, AMERICAN INSTITUTE OF CHEMICAL ENGINEERS, US, vol. 20, no. 3, 30 January 2004 (2004-01-30), pages 639-654, XP008155090, ISSN: 8756-7938, DOI: 10.1021/BP0200595 [retrieved on 2008-09-05]
  • JIANING QIAN ET AL: "A synthetic Protein G adsorbent based on the multi-component Ugi reaction for the purification of mammalian immunoglobulins", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 898, 30 March 2012 (2012-03-30), pages 15-23, XP028508900, ISSN: 1570-0232, DOI: 10.1016/J.JCHROMB.2012.03.043 [retrieved on 2012-04-21]
  • KABIR S: "IMMUNOGLOBULIN PURIFICATION BY AFFINITY CHROMATOGRAPHY USING PROTEIN A MIMETIC LIGANDS PREPARED BY COMBINATORIAL CHEMICAL SYNTHESIS", IMMUNOLOGICAL INVESTIGATIONS, INFORMA HEALTHCARE, US, vol. 31, no. 3/04, 1 January 2002 (2002-01-01), pages 263-278, XP008065713, ISSN: 0882-0139, DOI: 10.1081/IMM-120016245
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).