| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
|
Designated Extension States: |
|
BA ME |
| (30) |
Priority: |
30.09.2010 US 388501 P
|
| (43) |
Date of publication of application: |
|
09.03.2016 Bulletin 2016/10 |
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
|
11829686.2 / 2621496 |
| (73) |
Proprietors: |
|
- AstraZeneca AB
151 85 Södertälje (SE)
- Nektar Therapeutics
San Francisco, CA 94158 (US)
|
|
| (72) |
Inventors: |
|
- ASLUND, Bengt Leonard
151 85 Södertälje (SE)
- AURELL, Carl-Johan
151 85 Södertälje (SE)
- BOHLIN, Martin Hans
151 85 Södertälje (SE)
- SEBHATU, Tesfai
151 85 Södertälje (SE)
- YMEN, Bo Ingvar
151 85 Södertälje (SE)
- HEALY, Eric Thomas
San Francisco, CA 94158 (US)
- JENSEN, David Richard
San Francisco, CA 94158 (US)
- JONAITIS, David Thomas
West Lafayette, IN 47906-1076 (US)
- PARENT, Stephan
West Lafayette, IN 47906-1076 (US)
- LECHUGA-BALLESTEROS, David
San Jose, CA 95124 (US)
|
| (74) |
Representative: Boult Wade Tennant LLP |
|
Salisbury Square House
8 Salisbury Square
London EC4Y 8AP
London EC4Y 8AP (GB) |
| (56) |
References cited: :
WO-A1-2009/137086
WO-A2-2008/057579
|
WO-A2-2005/058367
|
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| |
|
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- NEUMANN THERESA A ET AL: "Evaluation of single oral doses of NKTR118 (PEG-naloxol)
as a peripheral opioid antagonist (POA): A double-blind placebo-controlled study in
healthy male subjects", JOURNAL OF CLINICAL PHARMACOLOGY, vol. 47, no. 9, 118, 1 September
2007 (2007-09-01), page 1210, XP009120642, ISSN: 0091-2700
- ODINEES A ET AL: "NKTR-118, AN ORAL PERIPHERAL OPIOID ANTAGONIST, HAS LOW POTENTIAL
FOR DRUG-DRUG INTERACTIONS", JOURNAL OF CLINICAL PHARMACOLOGY, vol. 49, no. 9, 141,
September 2009 (2009-09), page 1123, XP009120650, & 38TH ANNUAL MEETING OF THE AMERICAN-COLLEGE-OF-CLINICAL-PHARMACOLOGY;
SAN ANTONIO, TX, USA; SEPTEMBER 13 -15, 2009 ISSN: 0091-2700 Retrieved from the Internet:
URL:http://onlinelibrary.wiley.com/doi/10. 1177/00912700090490091001/pdf>
- NEUMANN T A ET AL: "Clinical investigation of NKTR-118 as a selective oral peripheral
opioid antagonist", POSTER PRESENTED AT THE ANNUAL CLINICAL MEETING OF THE AMERICAN
ACADEMY OF PAIN MANAGEMENT ; SEPTEMBER 27-30, 2007; LAS VEGAS, NV,, 27 September 2007
(2007-09-27), page POSTER27, XP001586734,
- ELDON M A ET AL: "NKTR-118 (oral PEG-naloxol), a PEGylated derivative of naloxone;
demonstration of selective peripheral opioid antagonism after oral administration
in preclinical models", POSTER PRESENTED AT THE ANNUAL CLINICAL MEETING OF THE AMERICAN
ACADEMY OF PAIN MANAGEMENT ; SEPTEMBER 27-30, 2007; LAS VEGAS, NV,, [Online] 27 September
2007 (2007-09-27), page POSTER28, XP001586735, Retrieved from the Internet: URL:http://www.nektar.com>
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