ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSKBAHRIS..MTNORSMESM..................JBDM Ver 2.0.15 (20th of December) - 2999001/0202104162992903CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120220608W172deBibliographieenBibliographyfrBibliographieEP15188944.1201109292016090820180201enenen388501 P20100930US2022060820222320160309201610202007152020292020020520200715AL20200715AT20200930BE20201015BG20200715CZ20200715DK20200715EE20200715FI20201016GR20200715HR20200929IE20201115IS20200715LT20200929LU20200715LV20200715MC20201015NO20200715PL20201116PT20200715RO20200715RS20200715SI20200715SK20200715SM20220608202223A61K 47/60 20170101AFI20190903BHEP A61K 45/06 20060101ALI20190903BHEP A61P 39/00 20060101ALI20190903BHEP C07D 489/04 20060101ALI20190903BHEP C07D 489/04 20130101 LI20130101BHEP A61K 47/60 20170801 LI20170802BHEP C07B2200/13 20130101 LA20170920BHEP A61P 25/00 20180101 LI20200320BHEP A61P 25/04 20180101 LI20200323BHEP A61P 39/00 20180101 LI20200331BHEP deKOMBINATION VON EINEM NALOXOL-PEG-KONJUGATE UND EINEM OPIOIDAGONISTenCOMBINATION OF A NALOXOL-PEG CONJUGATE AND AN OPIOID AGONISTfrCOMBINAISON D'UN CONJUGUÉ NALOXOL-PEG AVEC UN AGONISTE OPIOÏDEWO-A1-2009/137086WO-A2-2005/058367WO-A2-2008/057579NEUMANN THERESA A ET AL: "Evaluation of single oral doses of NKTR118 (PEG-naloxol) as a peripheral opioid antagonist (POA): A double-blind placebo-controlled study in healthy male subjects", JOURNAL OF CLINICAL PHARMACOLOGY, vol. 47, no. 9, 118, 1 September 2007 (2007-09-01), page 1210, XP009120642, ISSN: 0091-2700ODINEES A ET AL: "NKTR-118, AN ORAL PERIPHERAL OPIOID ANTAGONIST, HAS LOW POTENTIAL FOR DRUG-DRUG INTERACTIONS", JOURNAL OF CLINICAL PHARMACOLOGY, vol. 49, no. 9, 141, September 2009 (2009-09), page 1123, XP009120650, & 38TH ANNUAL MEETING OF THE AMERICAN-COLLEGE-OF-CLINICAL-PHARMACOLOGY; SAN ANTONIO, TX, USA; SEPTEMBER 13 -15, 2009 ISSN: 0091-2700 Retrieved from the Internet: URL:http://onlinelibrary.wiley.com/doi/10. 1177/00912700090490091001/pdf>NEUMANN T A ET AL: "Clinical investigation of NKTR-118 as a selective oral peripheral opioid antagonist", POSTER PRESENTED AT THE ANNUAL CLINICAL MEETING OF THE AMERICAN ACADEMY OF PAIN MANAGEMENT ; SEPTEMBER 27-30, 2007; LAS VEGAS, NV,, 27 September 2007 (2007-09-27), page POSTER27, XP001586734,ELDON M A ET AL: "NKTR-118 (oral PEG-naloxol), a PEGylated derivative of naloxone; demonstration of selective peripheral opioid antagonism after oral administration in preclinical models", POSTER PRESENTED AT THE ANNUAL CLINICAL MEETING OF THE AMERICAN ACADEMY OF PAIN MANAGEMENT ; SEPTEMBER 27-30, 2007; LAS VEGAS, NV,, [Online] 27 September 2007 (2007-09-27), page POSTER28, XP001586735, Retrieved from the Internet: URL:http://www.nektar.com>11829686.2262149620110929ASLUND, Bengt LeonardAstraZeneca R&D Södertälje151 85 SödertäljeSEAURELL, Carl-JohanAstraZeneca R&D Södertälje151 85 SödertäljeSEBOHLIN, Martin HansAstraZeneca R&D Södertälje151 85 SödertäljeSESEBHATU, TesfaiAstraZeneca R&D Södertälje151 85 SödertäljeSEYMEN, Bo IngvarAstraZeneca R&D Södertälje151 85 SödertäljeSEHEALY, Eric ThomasNektar Therapeutics 455 Mission Bay Boulevard Suite 100San Francisco, CA 94158USJENSEN, David RichardNektar Therapeutics 455 Mission Bay Boulevard Suite 100San Francisco, CA 94158USJONAITIS, David ThomasSSCI A Division of APTUIT 3065 Kent AvenueWest Lafayette, IN 47906-1076USPARENT, StephanSSCI A Division of APTUIT 3065 Kent AvenueWest Lafayette, IN 47906-1076USLECHUGA-BALLESTEROS, DavidSan Jose, CA 95124USAstraZeneca AB101095572SCB/P139444EP01151 85 SödertäljeSENektar Therapeutics101839370SCB/P139444EP01455 Mission Bay Boulevard Suite 100San Francisco, CA 94158USBoult Wade Tennant LLP101370347Salisbury Square House 8 Salisbury SquareLondon EC4Y 8APGBALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTRBA20151008ME20151008