PROCESS FOR THE PREPARATION OF HIGH PURITY AMORPHOUS PEMETREXED DISODIUM AND CRYSTALLINE FORMS OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3- D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID - Patent 2997031

(19)

(11)

EP 2 997 031 A1

(12)

(43)	Date of publication:
	23.03.2016 Bulletin 2016/12

(21)	Application number: 14732453.7

(22)	Date of filing: 16.05.2014

(51)

International Patent Classification (IPC):

C07D 487/04^(2006.01)

(86)	International application number:
	PCT/PL2014/000053

(87)	International publication number:
	WO 2014/185797 (20.11.2014 Gazette 2014/47)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
	Designated Extension States:
	BA ME

(30)

Priority:

17.05.2013 PL 40394213
30.04.2014 PL 40808914

(71)	Applicant: Instytut Farmaceutyczny
	01-793 Warsawa (PL)

(72)	Inventors:
	MICHALAK, Olga 04-847 Warszawa (PL) JATCZAK, Kamil 05-800 Pruszków (PL) PUCKO, Wieslaw 01-461 Warszawa (PL) WITKOWSKA, Anna 01-905 Warszawa (PL) LASZCZ, Marta 03-126 Warszawa (PL) BUJAK, Iwona 02-132 Warszawa (PL) GROMAN, Aleksandra 03-565 Warszawa (PL) CYBULSKI, Marcin 03-254 Warszawa (PL)

(74)	Representative: Krzywdzinska, Ewa
	Instytut Farmaceutyczny, ul. Rydygiera 8 01-793 Warszawa 01-793 Warszawa (PL)

(54)	PROCESS FOR THE PREPARATION OF HIGH PURITY AMORPHOUS PEMETREXED DISODIUM AND CRYSTALLINE FORMS OF N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3- D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID