ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................*JBDM Ver 1.7.2 (20 November 2019) - 2999001/03004340CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120201104W173deBibliographieenBibliographyfrBibliographieEP14763905.8201403142015082520171025enenen20131384336920130315US2020110420204520160413201615202007082020282019121620201104202045C12N 9/50 20060101AFI20170103BHEP A23L 33/00 20160101ALI20170103BHEP A61K 38/48 20060101ALI20170103BHEP A61P 1/14 20060101ALI20170103BHEP A61P 31/04 20060101ALI20170103BHEP deBEHANDLUNG VON GLUTENUNVERTRÄGLICHKEIT UND VERWANDTEN LEIDENenTREATMENT OF GLUTEN INTOLERANCE AND RELATED CONDITIONSfrTRAITEMENT DE L'INTOLÉRANCE AU GLUTEN ET D'ÉTATS ASSOCIÉSEP-A2- 2 090 662US-A1- 2012 225 050MARTIAL REY ET AL: "Addressing proteolytic efficiency in enzymatic degradation therapy for celiac disease", SCIENTIFIC REPORTS, vol. 6, 2 August 2016 (2016-08-02), page 30980, XP55313418, DOI: 10.1038/srep30980ALAN KADEK ET AL: "Expression and characterization of plant aspartic protease nepenthesin-1 from Nepenthes gracilis", PROTEIN EXPRESSION AND PURIFICATION., vol. 95, 21 December 2013 (2013-12-21), pages 121-128, XP055313738, SAN DIEGO, CA. ISSN: 1046-5928, DOI: 10.1016/j.pep.2013.12.005ATHAUDA SENARATH B P ET AL: "Enzymic and structural characterization of nepenthesin, a unique member of a novel subfamily of aspartic proteinases", BIOCHEMICAL JOURNAL, PORTLAND PRESS LTD, GB, vol. 381, no. Part 1, 1 July 2004 (2004-07-01), pages 295-306, XP002453530, ISSN: 0264-6021, DOI: 10.1042/BJ20031575TAKAHASHI KENJI: "Nepenthesin", HANDBOOK OF PROTEOLYTIC ENZYMES, VOLS 1 AND 2, 3RD EDITION ELSEVIER SCIENCE BV, SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 9 November 2012 (2012-11-09), pages 125-128, XP009192250,KEIKO KUBOTA ET AL: "Stability Profiles of Nepenthesin in Urea and Guanidine Hydrochloride: Comparison with Porcine Pepsin A", BIOSCIENCE BIOTECHNOLOGY BIOCHEMISTRY., vol. 74, no. 11, 23 November 2010 (2010-11-23), pages 2323-2326, XP55313435, TOKYO, JAPAN ISSN: 0916-8451, DOI: 10.1271/bbb.100391NAOYA HATANO ET AL: "Proteome Analysis of Pitcher Fluid of the Carnivorous Plant Nepenthes alata", JOURNAL OF PROTEOME RESEARCH., vol. 7, no. 2, 1 February 2008 (2008-02-01), pages 809-816, XP055313727, US ISSN: 1535-3893, DOI: 10.1021/pr700566dM. REY ET AL: "Nepenthesin from Monkey Cups for Hydrogen/Deuterium Exchange Mass Spectrometry", MOLECULAR & CELLULAR PROTEOMICS, vol. 12, no. 2, 29 November 2012 (2012-11-29), pages 464-472, XP055313730, US ISSN: 1535-9476, DOI: 10.1074/mcp.M112.025221AN CHUNG-IL ET AL: "Aspartic proteinases are expressed in pitchers of the carnivorous plant Nepenthes alata Blanco", PLANTA, SPRINGER VERLAG, DE, vol. 214, no. 5, 1 March 2002 (2002-03-01) , pages 661-667, XP002453529, ISSN: 0032-0935, DOI: 10.1007/S004250100665MAZORRA-MANZANO MA ET AL.: 'Structure-function characterization of the recombinant aspartic proteinase A1 from Arabidopsis thaliana' PHYTOCHEM vol. 71, no. 5-6, April 2010, pages 515 - 523, XP055292809STEPNIAK D ET AL.: 'Highly-efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease' AM J PHYSIOL vol. 291, pages G621 - G629, XP002741636TAKAHASHI K ET AL.: 'Nepenthesin, a unique member of a novel subfamily of aspartic proteinases: Enzymatic and structural characteristics' CURR PROT PEP SCI vol. 6, 2005, pages 513 - 525, XP0081810832017011020184407.320200707SCHRIEMER, Davidc/o Nepetx, LLC 1234 Airport Road, Suite 105Destin, Florida 32541-2924USMAN, Petrc/o Nepetx, LLC 1234 Airport Road, Suite 105Destin, Florida 32541-2924USMRAZEK, Hynekc/o Nepetx, LLC 1234 Airport Road, Suite 105Destin, Florida 32541-2924USREY, Martialc/o NEPETX, LLC 1234 Airport Road, Suite 105Destin, Florida 32541-2924USCodexis, Inc.100101341NEP-C-P1928EP200 Penobscot DriveRedwood City, CA 94063USGibson, Mark101231923Sagittarius IP Marlow International ParkwayMarlow SL7 1YLGBALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTRCA201400025820140314enWO201413892720140918201438