PREPARATION OF CHIRAL 1-METHYL-2,3,4,5-1H-BENZODIAZEPINES VIA ASYMMETRIC REDUCTION OF ALPHA-SUBSTITUTED STYRENES - Patent 3010887

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EP 3 010 887 A1

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(43)	Date of publication:
	27.04.2016 Bulletin 2016/17

(21)	Application number: 14731300.1

(22)	Date of filing: 20.06.2014

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International Patent Classification (IPC):

C07D 223/16^(2006.01)
C07C 69/635^(2006.01)
C07C 205/09^(2006.01)
C07C 209/48^(2006.01)
C07C 217/40^(2006.01)
C07C 253/30^(2006.01)
C07C 311/17^(2006.01)

C07C 67/03^(2006.01)
C07C 201/12^(2006.01)
C07C 209/34^(2006.01)
C07C 211/29^(2006.01)
C07C 233/18^(2006.01)
C07C 255/10^(2006.01)

(86)	International application number:
	PCT/EP2014/063048

(87)	International publication number:
	WO 2014/202765 (24.12.2014 Gazette 2014/52)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
	Designated Extension States:
	BA ME

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Priority:

21.06.2013 EP 13173237

(71)	Applicant: LEK Pharmaceuticals d.d.
	1526 Ljubljana (SI)

(72)	Inventors:
	STAVBER, Gaj 1526 Ljubljana (SI) GAZIC SMILOVIC, Ivana 1526 Ljubljana (SI) CLUZEAU, Jerome 1526 Ljubljana (SI) RICHTER, Frank A-6250 Kundl (AT)

(74)	Representative: Prüfer & Partner mbB Patentanwälte · Rechtsanwälte
	Sohnckestraße 12 81479 München 81479 München (DE)

(54)	PREPARATION OF CHIRAL 1-METHYL-2,3,4,5-1H-BENZODIAZEPINES VIA ASYMMETRIC REDUCTION OF ALPHA-SUBSTITUTED STYRENES