(19)
(11) EP 3 010 892 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
22.05.2019 Bulletin 2019/21

(45) Mention of the grant of the patent:
26.12.2018 Bulletin 2018/52

(21) Application number: 14738998.5

(22) Date of filing: 20.06.2014
(51) International Patent Classification (IPC): 
C07D 249/08(2006.01)
A61P 35/00(2006.01)
 A61K 31/497(2006.01)
(86) International application number:
PCT/US2014/043479
(87) International publication number:
WO 2014/205389 (24.12.2014 Gazette 2014/52)

(54)

1,2,4-TRIAZOLES AS NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

1,2,4-TRIAZOLE ALS NUKLEARTRANSPORTMODULATOREN UND VERWENDUNGEN DAVON

1,2,4-TRIAZOLES EN TANT QUE MODULATEURS DE TRANSPORT NUCLÉAIRE ET LEURS UTILISATIONS

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME

(30) Priority: 21.06.2013 US 201361838172 P

(43) Date of publication of application:
27.04.2016 Bulletin 2016/17

(60) Divisional application:
18202641.9

(73) Proprietor: Karyopharm Therapeutics Inc.
Newton, MA 02459 (US)

(72) Inventors:
  • BALOGLU, Erkan
    Stoneham, MA 02180 (US)
  • SHACHAM, Sharon
    Newton, MA 02459 (US)
  • MCCAULEY, Dilara
    Arlington, MA 02476 (US)
  • KASHYAP, Trinayan
    Framingham, MA 01701 (US)
  • SENAPEDIS, William
    Millis, MA 02054 (US)
  • LANDESMAN, Yosef
    Brookline, MA 02445 (US)
  • GOLAN, Gali
    99770 Mesilat Zion (IL)
  • KALID, Ori
    37025 Pardes Hanna (IL)
  • SHECHTER, Sharon
    Andover, MA 01810 (US)

(74) Representative: Snodin, Michael D. 
Park Grove IP BioCity Nottingham Pennyfoot Street
Nottingham NG1 1GF
Nottingham NG1 1GF (GB)


(56) References cited: : 
WO-A1-2011/109799
WO-A1-2013/019548
 WO-A1-2012/099807
WO-A1-2013/019561
   
  • BREKHOV, Y. ET AL.: "Cyanomethyltetrazoles II reactions of the methylene Moiety", ZHURNAL ORGANICHESKOI KHIMII, vol. 28, no. 9, 1992, pages 1921-1925, XP009179968,
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).