(19)

(11)

EP 3 010 929 A1

(12)

(43) Date of publication: 27.04.2016 Bulletin 2016/17 (21) Application number: 14812900.0 (22) Date of filing: 16.06.2014

(51) International Patent Classification (IPC):  C07H 19/23(2006.01) C07H 19/173(2006.01) C07H 19/167(2006.01) (86) International application number: PCT/US2014/042567 (87) International publication number: WO 2014/204861 (24.12.2014 Gazette 2014/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME (30) Priority: 17.06.2013 US 201361836060 P (71) Applicant: The Trustees of Columbia University in the City of New York New York, NY 10027 (US)	(72) Inventors: BESTOR, Timothy H. New York, NY 10014 (US) JU, Jingyue Englewood Cliffs, NJ 07632 (US) LI, Xiaoxu New York, NY 10025 (US) (74) Representative: Peters, Hajo  ZACCO GmbH Bayerstrasse 83 80335 München 80335 München (DE)